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. 2023 Jun;167(2):139-144.
doi: 10.5507/bp.2021.062. Epub 2021 Nov 15.

Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx

Richard Pink  1 , Jaroslav Michalek  2 , David Kral  1 , Michal Mozola  1 , Pavel Benes  1 , Saskova Lenka  1 , Zdenek Dvorak  1   3
Affiliations
Free article

Importance of evaluation of bone invasion type in squamous cell carcinomas of the oral cavity and oropharynx

Richard Pink et al. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2023 Jun.
Free article

Abstract

Aims: The objective of this study was to compare bone invasion type with histopathological, clinical and immunohistochemical prognostic factors.

Methods: The study included 49 patients who were treated for oral squamous cell carcinoma. Of which, 30 patients, with presence of bone invasion on histopathology, were divided according to the type of bone invasion (erosive, infiltrative, mixed). Each invasion type was compared to microvascular density using the CD34 marker.

Results: The bone invasion was observed in 30 out of 49 patients (61.22%). On McNemar's test, statistically significant association was observed between bone invasion types and histopathological grade. In contrast, no significant correlation was observed between bone invasion type, and tumour volume or nodal metastases. In tumours with bone invasion of the infiltrative type, higher frequency of locoregional relapses was observed. The 5-year survival, since diagnosis, was approximately 60% in the erosive group, 40% in the mixed group, and merely 15% in the infiltrative group.

Conclusion: Peritumoural microvascular density was not significantly related to bone invasion types. Whereas, a significantly higher intratumoural microvascular density was observed in infiltrative type of the bone invasion, when compared to the erosive and mixed type.

Keywords: head and neck neoplasms; histocytochemistry; maxillofacial surgery; neoplasm invasiveness; neoplasm staging; oral squamous cell carcinoma of head and neck; tumor grading.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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