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. 2022 Jan;36(1):e24120.
doi: 10.1002/jcla.24120. Epub 2021 Nov 16.

A high value of fibrinogen in immunoglobulin A nephropathy patients is associated with a worse renal tubular atrophy/interstitial fibrosis score

Mengyun Tu  1 , Sipin Hu  2 , Zhengqing Lou  1
Affiliations

A high value of fibrinogen in immunoglobulin A nephropathy patients is associated with a worse renal tubular atrophy/interstitial fibrosis score

Mengyun Tu et al. J Clin Lab Anal. 2022 Jan.

Abstract

Purpose: The purpose of our study was to investigate the relationship between serum fibrinogen value and renal tubular atrophy/interstitial fibrosis in immunoglobulin A nephropathy patients with eGFR ≥90 ml/min/1.73 m2 .

Patients and methods: Of 359 patients diagnosed with immunoglobulin A nephropathy after renal biopsy were enrolled in this retrospective study. Demographic, histopathological features, and clinical data were collected. The relationships among these factors were analyzed by using Student's t test, Mann-Whitney U test, Kruskal-Wallis test, Chi-square test, or Fisher's exact test, where appropriate. The logistic regression analysis was performed to examine the independent risk factors.

Results: Of 176 immunoglobulin A nephropathy patients with eGFR ≥90 ml/min/1.73 m2 were included in this study, and patients were classified into low fibrinogen (fibrinogen <304.6 mg/dl) and high fibrinogen (fibrinogen ≥304.6 mg/dl) groups, respectively. High fibrinogen groups had advanced age, a higher classification of renal tubular atrophy/interstitial fibrosis, and higher levels of systolic pressure, D-dimer, 24 h urine protein quantitation, nag enzyme. Multivariate logistic analysis showed that fibrinogen (OR = 1.018) was significantly associated with tubular atrophy/interstitial fibrosis.

Conclusion: Among patients with immunoglobulin A nephropathy, the higher levels of fibrinogen and uric acid may mean a higher score of tubular atrophy/interstitial fibrosis, which suggests the renal biopsy should be performed for these patients as early as possible to defined pathological classification, even though there is no obvious abnormal change in the test of renal function.

Keywords: fibrinogen; immunoglobulin A nephropathy; tubular atrophy/interstitial fibrosis; uric acid.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

FIGURE 1
FIGURE 1
Flow diagram for patient's enrollment
FIGURE 2
FIGURE 2
Box plot of the relationship between T‐score and serum fibrinogen levels
FIGURE 3
FIGURE 3
ROC analysis of renal tubular atrophy/interstitial fibrosis by fibrinogen
FIGURE 4
FIGURE 4
Calibration curves for predicting renal tubular atrophy/interstitial fibrosis probability by the model
FIGURE 5
FIGURE 5
The ROC curve of the logit model, fibrinogen, uric acid, and eGFR
See this image and copyright information in PMC

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