Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;15(18):1709-1719.
doi: 10.2217/bmm-2020-0722. Epub 2021 Nov 16.

Evaluation of a multimarker panel in chronic heart failure: a 10-year follow-up

Susanne Bauer  1 , Christina Strack  1 , Ekrem Ücer  1 , Stefan Wallner  2 , Ute Hubauer  1 , Andreas Luchner  3 , Lars Siegfried Maier  1 , Carsten Jungbauer  1
Affiliations

Evaluation of a multimarker panel in chronic heart failure: a 10-year follow-up

Susanne Bauer et al. Biomark Med. 2021 Dec.

Abstract

Aim: We assessed the 10-year prognostic role of 11 biomarkers with different pathophysiological backgrounds. Materials & methods/results: Blood samples from 144 patients with heart failure were analyzed. After 10 years of follow-up (median follow-up was 104 months), data regarding all-cause mortality were acquired. Regarding Kaplan-Meier analysis, all markers, except TIMP-1 and GDF-15, were significant predictors for all-cause mortality. We created a multimarker model with nt-proBNP, hs-TnT and IGF-BP7 and found that patients in whom all three markers were elevated had a significantly worse long-time prognosis than patients without elevated markers. Conclusion: In a 10-year follow-up, a combination of three biomarkers (NT-proBNP, hs-TnT, IGF-BP7) identified patients with a high risk of mortality.

Keywords: IGF-BP7; NT-proBNP; heart failure; hs-TnT; multimarker panel; prognostication.

PubMed Disclaimer

LinkOut - more resources