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Case Reports
. 2022 Jan-Feb;97(1):45-48.
doi: 10.1016/j.abd.2020.10.012. Epub 2021 Nov 14.

Basaloid follicular hamartoma associated with follicular mucinosis and inflammation

Solange Edelman  1 , Adriana Natalia Torres Huamani  2 , María Del Valle Centeno  2 , Andrea Bettina Cervini  2
Affiliations
Case Reports

Basaloid follicular hamartoma associated with follicular mucinosis and inflammation

Solange Edelman et al. An Bras Dermatol. 2022 Jan-Feb.

Abstract

Basaloid follicular hamartoma is a benign, superficial malformation of hair follicles that can be mistaken both clinical and histopathologically for basal cell carcinoma. Basaloid follicular hamartoma has been linked to a mutation in the PTCH-1 gene, which is part of the same pathway involved in Gorlin-Goltz syndrome. Here we present a 9-year-old patient with an asymptomatic congenital lesion on the forehead, which increased in size over the years. Histopathology showed a basaloid follicular hamartoma associated with follicular mucinosis and inflammation. Gorlin-Goltz syndrome was ruled out by clinical examination.

Keywords: Carcinoma, basal cell; Genes, tumor suppressor; Hamartoma.

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Figures

Figure 1
Figure 1
Rounded reddish plaque with warty areas.
Figure 2
Figure 2
Pinkish-orange lesion with scale formation especially at the perifollicular level without a distinctive melanocytic or vascular pattern.
Figure 3
Figure 3
Predominantly mononuclear dense inflammatory infiltrates are seen (Hematoxylin & eosin, ×400).
Figure 4
Figure 4
Alcian-blue-positive intercellular material possibly corresponding to mucin deposits. (Alcian blue, ×100).
Figure 5
Figure 5
Bcl-2 positive only in the outermost tumor cells; (IMQ, 100×).
Figure 6
Figure 6
CD-34 positive in stromal tumor cells; (IMQ, 40×).
See this image and copyright information in PMC

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