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. 2021 Nov 10:17:1165-1175.
doi: 10.2147/TCRM.S337256. eCollection 2021.

Drug-Related Problems Among Ambulatory Heart Failure Patients on Follow-Up at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Abate Wondesen Tsige  1 , Berhan Begashaw Yikna  2 , Birhanetensay Masresha Altaye  2
Affiliations

Drug-Related Problems Among Ambulatory Heart Failure Patients on Follow-Up at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Abate Wondesen Tsige et al. Ther Clin Risk Manag. .

Abstract

Purpose: The purpose of this study was to assess drug-related problems (DRPs) among ambulatory heart failure (HF) patients attending at medical referral clinic of Debre Berhan Comprehensive Specialized Hospital, Ethiopia.

Materials and methods: A hospital-based cross-sectional study was conducted among 344 HF patients. Drug-related problems were classified using modified Cipolle's DRP classification schemes and drug-drug interactions were assessed using Micromedex, up-to-date, and drug.com drug-drug interaction checkers. The data was entered into Epidata version 4.2.0 and analyzed using SPSS version 25.0 statistical software. Descriptive statistics were used to summarize patients' characteristics. Univariable and multivariable binary logistic regression analysis was performed to identify associated factors with dependent variables. P < 0.05 was considered statistically significant.

Results: The mean age of the study participants was 53.38 ± 18.84 years and nearly half (45%) were in the age group of 31-60 years. Drug-related problems were found in 80.8% of HF patients. A total of 416 DRPs were identified. Adverse drug reaction (35.58%) was the top DRPs identified followed by the need for additional drug therapy (30.53%) and ineffective drug therapy (26.9%), respectively. Diuretics (45%), beta-blockers (BBs) (12.42%), and angiotensin-converting enzyme inhibitors (ACEIs) (10%) were the commonly used drug classes by study participants. The presence of comorbidity (p ˂ 0.001) and level of education of study participants (p = 0.03) had a significant association with the occurrence of DRPs.

Conclusion: The prevalence of DRPs among ambulatory HF patients was high. The presence of comorbidity and the educational level of study participants had a significant association with the occurrence of DRPs. Checking potential drug-drug interactions before starting a new therapy, monitoring adverse drug reactions, ensuring sustainable availability of medications, and regular education programs are recommended to minimize DRPs.

Keywords: Cipolle’s DRP classification scheme; Ethiopia; drug-related problem; heart failure.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Conceptual framework showing factors involved in drug-related problems.
Figure 2
Figure 2
Etiology of heart failure participants attending at medical referral clinic of DBCSH from February to June 2021. Others; Degenerative Valvular Heart Disease, Cor-pulmonale, Congenital Heart Disease.
Figure 3
Figure 3
Co-morbid conditions of heart failure participants attending at medical referral clinic of DBCSH from February to June 2021. Others: Chronic kidney disease (CKD), Benign prostate hyperplasia (BPH), peripheral arterial disease (PAD), anemia, chronic liver disease (CLD), left atrial thrombus, polycythemia, major depressive disorder (MDD), pulmonary thrombus embolism, TB pericarditis, systemic lupus erythematosus, diabetic mellitus, epilepsy.
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References

    1. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129–2200. - PubMed
    1. Lippi G, Sanchis-Gomar F. Global epidemiology and future trends of heart failure. AME Med J. 2020;5:15. doi:10.21037/amj.2020.03.03 - DOI
    1. Glezeva N, Gallagher J, Ledwidge M, et al. Heart failure in sub-Saharan Africa: a review of the etiology of heart failure and the role of point-of-care biomarker diagnostics. Trop Med Int Health. 2015;20(5):581–588. doi:10.1111/tmi.12461 - DOI - PubMed
    1. Ali S, Misganaw A, Worku A, et al. The burden of cardiovascular diseases in Ethiopia from 1990 to 2017: evidence from the global burden of disease study. Int Health. 2020;13(4):318–326. - PMC - PubMed
    1. Chiatti C, Bustacchini S, Furneri G, et al. The economic burden of inappropriate drug prescribing, lack of adherence and compliance, adverse drug events in older people: a systematic review. Drug Saf. 2012;35(Suppl 1):73–87. doi:10.1007/BF03319105 - DOI - PubMed