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. 2021 Oct 15;13(10):11883-11889.
eCollection 2021.

The effect of fluoxetine combined with repetitive transcranial magnetic stimulation on the psychological emotions and cognitive and neurological functions of acute post-stroke depression patients

Fangzhou Yu  1 , Ru He  1
Affiliations

The effect of fluoxetine combined with repetitive transcranial magnetic stimulation on the psychological emotions and cognitive and neurological functions of acute post-stroke depression patients

Fangzhou Yu et al. Am J Transl Res. .

Abstract

Objective: This research was designed to probe into the effects of fluoxetine combined with repetitive transcranial magnetic stimulation (rTMS) on the psychological emotions and the cognitive and neurological functions of acute post-stroke depression patients.

Methods: This experiment recruited 115 acute post-stroke depression patients who were treated in our hospital from February 2018 to April 2020 as the study cohort. 55 of the patients were treated with fluoxetine, and 60 were treated with fluoxetine combined with rTMS. Both groups were treated for 2 months. The self-rating anxiety scale (SAS), the self-rating depression scale (SDS), the National Institutes of Health stroke scale (NIHSS), the mini mental state scale (MMSE), the Barthel index, and the quality of life scale (SF-36) scores were observed.

Results: Compared with the control group (CG), the SAS, SDS, and NIHSS scores in the research group (RG) decreased, while the MMSE and Barthel index scores increased (P < 0.05). After the treatment, the SF-36 scores in the RG were higher than they were in the CG (P < 0.05).

Conclusion: Fluoxetine combined with rTMS can effectively improve the psychological emotions and the cognitive and neurological functions of acute post-stroke depression patients, so it is worthy of clinical promotion.

Keywords: Fluoxetine; acute stroke; cognitive function; neural function; psychological emotion; repetitive transcranial magnetic stimulation.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
The SAS, SDS, NIHSS, MMSE scores. A. The SAS scores in the RG were decreased after the treatment and were lower than the SAS scores in the CG. B. The SDS scores in the RG were decreased after the treatment and were lower than the scores in the CG. C. The NIHSS scores in the RG decreased after the treatment and were lower than they were in the CG. D. The MMSE scores in the RG increased after the treatment and were higher than they were in the control group. Note: * indicates that there is a significant difference between the two groups (P < 0.05).
Figure 2
Figure 2
The Barthel index scores. After the treatment, the Barthel index scores in the RG increased and were higher than they were in the CG. Note: * indicates that there is a significant difference between the two groups (P < 0.05).
Figure 3
Figure 3
SF-36 score. A. The SF-36 scores of the patients in the RG after the treatment were higher than the SF-36 scores in the CG. B. The mental health scores of the SF-36 in the RG after the treatment were higher than the SF-36 mental health scores in the CG. Note: * indicates that there is a significant difference between both groups (P < 0.05).
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References

    1. Sarfo FS, Ulasavets U, Opare-Sem OK, Ovbiagele B. Tele-rehabilitation after stroke: an updated systematic review of the literature. J Stroke Cerebrovasc Dis. 2018;27:2306–2318. - PMC - PubMed
    1. Coupland AP, Thapar A, Qureshi MI, Jenkins H, Davies AH. The definition of stroke. J R Soc Med. 2017;110:9–12. - PMC - PubMed
    1. Frontera JA, Lewin JJ 3rd, Rabinstein AA, Aisiku IP, Alexandrov AW, Cook AM, del Zoppo GJ, Kumar MA, Peerschke EI, Stiefel MF, Teitelbaum JS, Wartenberg KE, Zerfoss CL. Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the neurocritical care society and society of critical care medicine. Neurocrit Care. 2016;24:6–46. - PubMed
    1. Qureshi AI, Palesch YY, Barsan WG, Hanley DF, Hsu CY, Martin RL, Moy CS, Silbergleit R, Steiner T, Suarez JI, Toyoda K, Wang Y, Yamamoto H, Yoon BW ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network. Intensive blood-pressure lowering in patients with acute cerebral hemorrhage. N Engl J Med. 2016;375:1033–1043. - PMC - PubMed
    1. Tsivgoulis G, Zand R, Katsanos AH, Turc G, Nolte CH, Jung S, Cordonnier C, Fiebach JB, Scheitz JF, Klinger-Gratz PP, Oppenheim C, Goyal N, Safouris A, Mattle HP, Alexandrov AW, Schellinger PD, Alexandrov AV. Risk of symptomatic intracerebral hemorrhage after intravenous thrombolysis in patients with acute ischemic stroke and high cerebral microbleed burden: a meta-analysis. JAMA Neurol. 2016;73:675–683. - PubMed

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