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Review
. 2021 Oct 19:26:1066-1078.
doi: 10.1016/j.omtn.2021.10.010. eCollection 2021 Dec 3.

Non-coding RNA basis of muscle atrophy

Qi Liu  1   2 , Jiali Deng  1   2 , Yan Qiu  1   2 , Juan Gao  1   2 , Jin Li  1   2 , Longfei Guan  3 , Hangil Lee  4 , Qiulian Zhou  1   2 , Junjie Xiao  1   2
Affiliations
Review

Non-coding RNA basis of muscle atrophy

Qi Liu et al. Mol Ther Nucleic Acids. .

Abstract

Muscle atrophy is a common complication of many chronic diseases including heart failure, cancer cachexia, aging, etc. Unhealthy habits and usage of hormones such as dexamethasone can also lead to muscle atrophy. However, the underlying mechanisms of muscle atrophy are not completely understood. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), play vital roles in muscle atrophy. This review mainly discusses the regulation of ncRNAs in muscle atrophy induced by various factors such as heart failure, cancer cachexia, aging, chronic obstructive pulmonary disease (COPD), peripheral nerve injury (PNI), chronic kidney disease (CKD), unhealthy habits, and usage of hormones; highlights the findings of ncRNAs as common regulators in multiple types of muscle atrophy; and summarizes current therapies and underlying mechanisms for muscle atrophy. This review will deepen the understanding of skeletal muscle biology and provide new strategies and insights into gene therapy for muscle atrophy.

Keywords: aging; heart failure; lncRNA; microRNA; muscle atrophy; non-coding RNA.

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Conflict of interest statement

The authors declare no competing interests.

Figures

None
Graphical abstract
Figure 1
Figure 1
Different inducers lead to muscle atrophy through ncRNAs
Figure 2
Figure 2
Exercise protects against muscle atrophy through ncRNAs
See this image and copyright information in PMC

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