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Case Reports
. 2021 Oct 27:26:e01323.
doi: 10.1016/j.idcr.2021.e01323. eCollection 2021.

Pneumocystis jirovecii pneumonia in a X-linked chronic granulomatous disease female carrier

Vasiliki Kalotychou  1 , Demetrios Mermigkis  2 , Maria G Kanariou  3 , Marianna Tzanoudaki  3 , Vasiliki Epameinondas Georgakopoulou  2 , Irene Kourbeti  1 , George L Daikos  1
Affiliations
Case Reports

Pneumocystis jirovecii pneumonia in a X-linked chronic granulomatous disease female carrier

Vasiliki Kalotychou et al. IDCases. .

Abstract

The X-chromosome linked (XL) female carriers of chronic granulomatous disease (CGD) are considered to have no risk for infection. Herein we present a female CGD XL-carrier who developed Pneumocystis jirovecii pneumonia and Serratia marcescens infection associated with age-related skewing of X-chromosome inactivation.

Keywords: Chronic Granulomatous Disease; Neutrophils’ oxidative activity; Pneumocystis jirovecii; X-chromosome inactivation; X-linked carrier.

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Conflict of interest statement

The authors have no conflict to declare.

Figures

Fig. 1
Fig. 1
Flow cytometry plots from the dihydrorhodamine assay. Unstimulated (A) and PMA stimulated (B) neutrophils from a normal control. Patient’s neutrophils exhibited the typical CGD XL- carrier bimodal distribution upon PMA stimulation; in 2005, 34% of neutrophils generated normal oxidative activity (C), in 2018, 6% of neutrophils had normal oxidative activity (D).
See this image and copyright information in PMC

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