Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Oct 26;9(30):9236-9243.
doi: 10.12998/wjcc.v9.i30.9236.

Diagnosis and treatment of primary pulmonary enteric adenocarcinoma: Report of Six cases

Ling-Fang Tu  1 , Ling-Yan Sheng  1 , Jian-Ying Zhou  1 , Xue-Fen Wang  1 , Yue-Hong Wang  1 , Qian Shen  1 , Yi-Hong Shen  2
Affiliations
Case Reports

Diagnosis and treatment of primary pulmonary enteric adenocarcinoma: Report of Six cases

Ling-Fang Tu et al. World J Clin Cases. .

Abstract

Background: Primary pulmonary enteric adenocarcinoma (PEAC) is a very rare subtype of invasive adenocarcinoma, and there have been no large studies on PEAC to date. Therefore, it is necessary to obtain much more information about the clinical and pathological features, diagnosis, differential diagnosis, and treatment of PEAC.

Case summary: All clinical data of six patients with confirmed PEAC from 2013 to 2018 were collected, and data on diagnosis, differential diagnosis, and treatment of PEAC are discussed combined with all the associated literature. The mean age of six patients was 64.0 ± 5.6 (59-73) years old. Their clinical manifestations were heterogeneous, and during their disease course, there were no gastrointestinal symptoms. There was no evidence from colonoscopy or imaging studies to suggest digestive tract tumors or new metastases. The most commonly mutated gene was KRAS (50.0%), and the pathological features of the six cases were similar to those of colorectal cancer. CDX2 (83.3%) and CK7 (66.7%) had the highest positive rates upon immunohistochemical examination. In the associated literature, 252 cases were identified, and the most commonly mutated gene was KRAS (42.9%). Additionally, CDX2 (68.3%) and CK7 (85.8%) had the highest positive rates. Patients mainly received surgery, chemotherapy, and radiotherapy, immunotherapy was not included.

Conclusion: Positive results for CDX2 and CK7 play an important role in the diagnosis and differential diagnosis of PEAC, and immunotherapy or targeted therapy focused on KRAS needs to be further studied for the treatment of PEAC.

Keywords: Case report; Diagnosis; Immunohistochemistry; KRAS; Pulmonary enteric adenocarcinoma; Treatment.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: The authors declare that they have no conflict of interest for this manuscript.

Figures

Figure 1
Figure 1
Chest computed tomography results of patients with primary pulmonary enteric adenocarcinoma. A: Case 4 with pulmonary enteric adenocarcinoma (PEAC) whose lesion was located in the right upper lobe; B: Case 1 with PEAC whose large lesion was located in the right lung, with mediastinal lymph node metastasis.
Figure 2
Figure 2
Pathology of case 6 with pulmonary enteric adenocarcinoma (HE staining). A: × 100; B: × 400.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lin LI, Xu CW, Zhang BO, Liu RR, Ge FJ, Zhao CH, Jia RU, Qin QH, Stojsic J, Wang Y, Xu JM. Clinicopathological observation of primary lung enteric adenocarcinoma and its response to chemotherapy: A case report and review of the literature. Exp Ther Med. 2016;11:201–207. - PMC - PubMed
    1. Tsao MS, Fraser RS. Primary pulmonary adenocarcinoma with enteric differentiation. Cancer. 1991;68:1754–1757. - PubMed
    1. Ou SH, Kawaguchi T, Soo RA, Kitaichi M. Rare subtypes of adenocarcinoma of the lung. Expert Rev Anticancer Ther. 2011;11:1535–1542. - PubMed
    1. László T, Lacza A, Tóth D, Molnár TF, Kálmán E. Pulmonary enteric adenocarcinoma indistinguishable morphologically and immunohistologically from metastatic colorectal carcinoma. Histopathology. 2014;65:283–287. - PubMed
    1. Wang CX, Liu B, Wang YF, Zhang RS, Yu B, Lu ZF, Shi QL, Zhou XJ. Pulmonary enteric adenocarcinoma: a study of the clinicopathologic and molecular status of nine cases. Int J Clin Exp Pathol. 2014;7:1266–1274. - PMC - PubMed

Publication types