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. 2022 Jan;39(1):151-152.
doi: 10.1111/pde.14865. Epub 2021 Nov 17.

Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment

Penelope Kallis  1 , Elizabeth Bisbee  1 , Cheryl Garganta  2 , Jennifer J Schoch  1
Affiliations

Rapid improvement of skin lesions in CHILD syndrome with topical 5% simvastatin ointment

Penelope Kallis et al. Pediatr Dermatol. 2022 Jan.

Abstract

Congenital hemidysplasia with ichthyosiform erythroderma and limb defects (CHILD) syndrome is a rare X-linked dominant disorder of cholesterol synthesis characterized by unilateral ichthyosiform dermatitis with ipsilateral limb hypoplasia. Recently, pathogenesis-based treatment has demonstrated improvement of skin lesions with statins by decreasing formation of cholesterol intermediates through inhibition of cholesterol synthesis. We report a 10-month-old girl who presented with unilateral scaly ptychotropic plaques, who experienced rapid, near-complete clearance with topical 5% simvastatin monotherapy twice daily.

Keywords: CHILD syndrome; drug therapy; ichthyosis; simvastatin; statin.

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References

REFERENCES

    1. Christiansen AG, Koppelhus U, Sommerlund M. Skin abnormalities in CHILD syndrome successfully treated with pathogenesis-based therapy. Acta Derm Venereol. 2015;95(6):752-753.
    1. Paller AS, van Steensel MA, Rodriguez-Martin M, et al. Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism. J Invest Dermatol. 2011;131(11):2242-2248.
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