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. 2021 Nov 18;77(5-6):219-223.
doi: 10.1515/znc-2021-0096. Print 2022 May 25.

A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Truong Nhat Van Do  1   2 , Hai Xuan Nguyen  1   2 , Tho Huu Le  1   2 , Phu Hoang Dang  1   2 , Mai Thanh Nguyen  1   2 , Mai Thanh Thi Nguyen  1   3   2 , Nhan Trung Nguyen  1   3   2
Affiliations

A new diphenylheptanoid from the rhizomes of Curcuma zedoaria

Truong Nhat Van Do et al. Z Naturforsch C J Biosci. .

Abstract

A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2-5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).

Keywords: Curcuma zedoaria; α-glucosidase inhibitor; rhizomes.

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