Biomarker-Driven Prognostication in Merkel Cell Carcinoma: A Paradigm for Personalized Therapy

Beth A Helmink^{1

2}, George Ansstas^{3

2}, Ryan C Fields^{4

5}

Affiliations

¹ Section of Surgical Oncology, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
² Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
³ Department of Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA.
⁴ Section of Surgical Oncology, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. rcfields@wustl.edu.
⁵ Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. rcfields@wustl.edu.

Editorial

Beth A Helmink et al. Ann Surg Oncol. 2022 Mar.

. 2022 Mar;29(3):1498-1501.

doi: 10.1245/s10434-021-11055-1. Epub 2021 Nov 17.

Beth A Helmink^{1

2}, George Ansstas^{3

2}, Ryan C Fields^{4

5}

¹ Section of Surgical Oncology, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
² Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
³ Department of Medical Oncology, Washington University School of Medicine, St. Louis, MO, USA.
⁴ Section of Surgical Oncology, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. rcfields@wustl.edu.
⁵ Alvin J. Siteman Comprehensive Cancer Center, Washington University School of Medicine, St. Louis, MO, USA. rcfields@wustl.edu.

No abstract available

References

1. Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, et al. Merkel cell carcinoma: current US incidence and projected increases based on changing demographics. J Am Acad Dermatol. 2018;78(3):457–63. https://doi.org/10.1016/j.jaad.2017.10.028 . - DOI - PubMed
1. Harms KL, Healy MA, Nghiem P, Sober AJ, Johnson TM, Bichakjian CK, et al. Analysis of prognostic factors from 9387 merkel cell carcinoma cases forms the basis for the new 8th edition AJCC staging system. Ann Surg Oncol. 2016;23(11):3564–71. https://doi.org/10.1245/s10434-016-5266-4 . - DOI - PubMed
1. Colunga A, Pulliam T, Nghiem P. Merkel cell carcinoma in the age of immunotherapy: facts and hopes. Clin Cancer Res. 2018;24:2035–43. https://doi.org/10.1158/1078-0432.CCR-17-0439 . - DOI - PubMed
1. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096–100. https://doi.org/10.1126/science.1152586 . - DOI - PubMed - PMC
1. Pietropaolo V, Prezioso C, Moens U. Merkel cell polyomavirus and Merkel cell carcinoma. Cancers (Basel). 2020. https://doi.org/10.3390/cancers12071774 . - DOI - PubMed - PMC