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Review
. 2022 Jan;49(1):45-52.
doi: 10.1007/s10396-021-01160-9. Epub 2021 Nov 17.

How to standardize measurement of global longitudinal strain

Tomoko Negishi  1   2   3 , Kazuaki Negishi  4   5   6
Affiliations
Review

How to standardize measurement of global longitudinal strain

Tomoko Negishi et al. J Med Ultrason (2001). 2022 Jan.

Abstract

Global longitudinal strain (GLS) is a robust and sensitive marker of left-ventricular systolic function, reflecting longitudinal shortening of the ventricle. A growing body of evidence indicates its superiority in identifying subclinical, early alterations in cardiac function compared to traditional markers, such as ejection fraction. Therefore, there is a growing demand to assess GLS in clinical settings, but limited availability on how to obtain GLS accurately and appropriately in the current literature. This review summarizes key aspects of GLS measurement, including image acquisition, post-processing, and training/experience needed to facilitate the clinical implication with standardization.

Keywords: Experience; Global longitudinal strain (GLS); Reproducibility; Standardization; Vendor difference.

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