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Review
. 2021 Oct 28;27(40):6861-6873.
doi: 10.3748/wjg.v27.i40.6861.

Management of hepatitis B and C in special population

Anand V Kulkarni  1 , Nageshwar Reddy Duvvuru  2
Affiliations
Review

Management of hepatitis B and C in special population

Anand V Kulkarni et al. World J Gastroenterol. .

Abstract

Chronic viral hepatitis is one of the leading causes of cirrhosis worldwide. Chronic hepatitis B is more common in the Asia-Pacific region due to the larger population and lower screening availability. Hepatitis C predominates in the west due to injection drug abuse. The discovery of (oral) direct-acting antiviral agents (DAAs) has changed the landscape of chronic hepatitis C (CHC) management. Nucleos(t)ide analogs (NUCs) have also changed the approach to the treatment of chronic hepatitis B (CHB). Oral NUCs and DAAs have excellent efficacy and patient acceptance as well as a lower risk of resistance. However, certain populations have no robust data and safety and efficacy of such oral drugs is still evolving. In this review, we provide an overview of the management of CHB and CHC in special populations, such as those with chronic kidney disease, pregnant women, healthcare workers, and those undergoing chemo- or immunosuppressive therapy.

Keywords: Chronic kidney disease; Health care professionals; Hepatitis B; Hepatitis C; Pregnancy; Tenofovir.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Management of coinfection. Created with biorender.com. HIV: Human immunodeficiency virus; ART: Antiretroviral therapy; 3TC: Lamivudine; FTC: Emtricitabine; TDF: Tenofovir disoproxil fumarate; TAF: Tenofovir alafenamide fumarate; DAA: Directly acting antiviral agents; SOF: Sofosbuvir; VEL: Velpatasvir; GLE: Glecaprevir; PIB: Pibrentasvir.
Figure 2
Figure 2
Indications and safety of drugs in special circumstances for hepatitis B. Created with biorender.com. TAF: Tenofovir alafenamide fumarate; TDF: Tenofovir disoproxil fumarate; ETV: Entecavir.
Figure 3
Figure 3
Indications and safety of drugs in special circumstances for hepatitis C. Created with biorender.com. GLE: Glecaprevir; PIB: Pibrentasvir; SOF: Sofosbuvir; VEL: Velpatasvir; LDV: Ledipasvir; GZR: Grazoprevir; EBR: Elbasvir.
See this image and copyright information in PMC

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