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Review
. 2021 Sep 9;18(16):3644-3651.
doi: 10.7150/ijms.46834. eCollection 2021.

The Peripheral Immune System and Traumatic Brain Injury: Insight into the role of T-helper cells

Wangxiao Bao  1 , Yajun Lin  1 , Zuobing Chen  1
Affiliations
Review

The Peripheral Immune System and Traumatic Brain Injury: Insight into the role of T-helper cells

Wangxiao Bao et al. Int J Med Sci. .

Abstract

Emerging evidence suggests that immune-inflammatory processes are key elements in the physiopathological events associated with traumatic brain injury (TBI). TBI is followed by T-cell-specific immunological changes involving several subsets of T-helper cells and the cytokines they produce; these processes can have opposite effects depending on the disease course and cytokine concentrations. Efforts are underway to identify the T-helper cells and cytokine profiles associated with prognosis. These predictors may eventually serve as effective treatment targets to decrease morbidity and mortality and to improve the management of TBI patients. Here, we review the immunological response to TBI, the possible molecular mechanisms of this response, and therapeutic strategies to address it.

Keywords: T-helper cell; cytokines; traumatic brain injury.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Possible mechanism and the interactions between brain and systemic immunity response after traumatic brain injury (TBI).
See this image and copyright information in PMC

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