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. 2021 Nov 1;4(11):e2135135.
doi: 10.1001/jamanetworkopen.2021.35135.

Companion Tumor Sequencing to Assess the Clinical Significance of Germline Sequencing in Children With Cancer

Tinaye Mutetwa  1 , Catherine Goudie  2 , William D Foulkes  2   3 , Paz Polak  1   4
Affiliations

Companion Tumor Sequencing to Assess the Clinical Significance of Germline Sequencing in Children With Cancer

Tinaye Mutetwa et al. JAMA Netw Open. .

Abstract

This case-control study assesses the clinical significance of germline sequencing in children with cancer.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Foulkes reported grants from AstraZeneca in the form of funding to clinical lab outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Zygosity Status of hmGPVs in Pediatric and Adult Tumors
Depicted are high/moderate-penetrance (hm) germline pathogenic or likely pathogenic variants (here, combined as germline pathogenic variants [hmGPVs]) present in tumors associated or not associated with the altered genes for pediatric and adult tumors. The P values indicated were obtained from running comparisons of proportions tests. A decision on whether pediatric tumors were associated or not associated was determined by C.G. and W.D.F. For adult tumors, W.D.F. made the determinations alone. Please see the eMethods in the Supplement for more details.
See this image and copyright information in PMC

References

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