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. 2022 May;42(3):266-280.
doi: 10.1111/scd.12669. Epub 2021 Nov 18.

Oral manifestations of multisystemic inflammatory syndrome in children (MIS-C) and Kawasaki disease associated to COVID-19: A systematic review

Rebeca Barros Nascimento  1 , Nara Santos Araujo  1 , Jamerson Carvalho Silva  2 , Flávia Caló Aquino Xavier  3
Affiliations

Oral manifestations of multisystemic inflammatory syndrome in children (MIS-C) and Kawasaki disease associated to COVID-19: A systematic review

Rebeca Barros Nascimento et al. Spec Care Dentist. 2022 May.

Abstract

Aims: Multisystemic inflammatory syndrome in children (MIS-C) is a condition noted in some children asymptomatic but positive to Sars-cov-2 antibody and it presents clinical and laboratory changes similar to Kawasaki disease (KD). Oral changes have also been observed. This systematic review evaluated oral manifestations detected in children with MIS-C and KD associated to COVID-19.

Methods and results: This work was registered at PROSPERO (#CRD42020225909), following PRISMA guidelines. A comprehensive research was conducted in MEDLINE, Web of Science, EMBASE, LILACS, Scopus, and Grey Literature through August 2021, based on original research evaluating children diagnosed with MIS-C or KD related to COVID-19. Two authors independently screened all retrieved references. Twenty five selected studies evaluated 624 children, mean age 8.78 years. The assessment of the risk of bias (ROB) showed that most of them presented low ROB. Oral manifestations were erythematous mucous membrane, oral ulcers lesions, dry, swollen and cracked lips, and strawberry tongue.

Conclusion: MIS-C and KD share the same oral manifestations and their identification may lead to an early diagnosis.

Keywords: COVID-19; Kawasaki disease; multisystem inflammatory syndrome in children; oral manifestations; pediatric multisystem inflammatory syndrome.

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Conflict of interest statement

The authors declared that there is no conflict of interest. No financial or non‐financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

Figures

FIGURE 1
FIGURE 1
Flow chart of review conduction
See this image and copyright information in PMC

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