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Editorial
. 2021 Dec 1;49(12):2154-2157.
doi: 10.1097/CCM.0000000000005319.

Orange You Wishing There Were Definitive Randomized Controlled Trials Already?

David N Hager  1 , Ankita Agarwal  2 , Bram Rochwerg  3   4
Affiliations
Editorial

Orange You Wishing There Were Definitive Randomized Controlled Trials Already?

David N Hager et al. Crit Care Med. .

Erratum in

No abstract available

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Conflict of interest statement

Dr. Hager disclosed off-label product use of ascorbic acid. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1.
Figure 1.
In trial sequential analysis (TSA), the cumulative z score (y-axis) is plotted against number of participants. The Z-curve is a plot of the cumulative z score as each trial is added to the analysis. In an analysis that favors an intervention, the Z-curve will cross the TSA boundary of benefit (Z-curve A). In an analysis that is unlikely to ever demonstrate benefit or harm, the Z-curve will cross into the futility area (Z-curve B). In an analysis that favors the control, the Z-curve would cross the TSA boundary of harm.
See this image and copyright information in PMC

Comment on

References

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