Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan;21(1):226-228.e1.
doi: 10.1016/j.cgh.2021.11.011. Epub 2021 Nov 16.

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Dhiraj Yadav  1 , David C Whitcomb  2 , Gong Tang  3 , Adam Slivka  4 , Melena Bellin  5 ; North American Pancreatitis Studies Consortium
Collaborators, Affiliations

Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Dhiraj Yadav et al. Clin Gastroenterol Hepatol. 2023 Jan.

Abstract

Pancreatogenic diabetes mellitus, also termed type 3c diabetes (T3cD), or glucose intolerance develops in 25%-75% of adults with chronic pancreatitis (CP). The primary pathophysiologic defect in T3cD is insulin deficiency, thought to result largely from "bystander" injury to the islets from fibrotic changes in the exocrine pancreas and cytokine-induced beta cell dysfunction from intrapancreatic inflammation.1.

Trial registration: ClinicalTrials.gov NCT01545167.

PubMed Disclaimer

Publication types

Associated data