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Editorial
. 2022 Jan;81(1):1-2.
doi: 10.1016/j.eururo.2021.10.025. Epub 2021 Nov 15.

Targeting c-Met to Improve Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma

Andrea Katharina Lindner  1 , Martin Pichler  2 , Martin Thurnher  3 , Renate Pichler  4
Affiliations
Editorial

Targeting c-Met to Improve Immune Checkpoint Inhibition in Metastatic Renal Cell Carcinoma

Andrea Katharina Lindner et al. Eur Urol. 2022 Jan.

Abstract

c-Met inhibition has direct antitumor effects on proliferation, angiogenesis, and metastasis, and indirect antitumor effects via prevention of the induction of immunosuppressive mechanisms (PD-L1, TGFβ, IDO1). c-Met inhibition is key to overcome resistance to immune checkpoint inhibition and to maximize the efficacy of immunotherapy.

Keywords: Cabozantinib; Immunotherapy; RCC; Resistance; c-MET.

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