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Clinical Trial
. 1978 May;135(5):570-2.
doi: 10.1176/ajp.135.5.570.

Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report

F Quitkin, A Rifkin, J Kane, J R Ramos-Lorenzi, D F Klein
Clinical Trial

Prophylactic effect of lithium and imipramine in unipolar and bipolar II patients: a preliminary report

F Quitkin et al. Am J Psychiatry. 1978 May.

Abstract

Relapse rates of the first 35 unipolar and bipolar II manic-depressive patients who entered the controlled phase of a continuing evaluation of the prophylactic value of lithium alone or in combination with imipramine were analyzed. Lithium had a prophylactic effect in unipolar patients and possibly in bipolar II patients. Imipramine did not have a prophylactic effect in either group of patients.

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