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. 2021 Nov 18;11(1):22501.
doi: 10.1038/s41598-021-02032-5.

A demographic and clinical panorama of a sixteen-year cohort of soft tissue sarcoma patients in Brazil

Luiza Ohasi de Figueiredo  1   2 , Augusto Afonso Guerra Júnior  3 , Francisco de Assis Acurcio  3 , Alessandra Maciel Almeida  3 , Mariângela Leal Cherchiglia  4 , Alberto Julius Alves Wainstein  5   6 , Luiz Claudio Santos Thuler  7 , Angélica Nogueira-Rodrigues  5   4
Affiliations

A demographic and clinical panorama of a sixteen-year cohort of soft tissue sarcoma patients in Brazil

Luiza Ohasi de Figueiredo et al. Sci Rep. .

Abstract

Little is known about soft tissue sarcomas (STS) in Brazil, once the federal statistics regarding estimates on incidence and mortality of the most common cancers that affect the Brazilian population currently do not include STS. This study aims to perform a broad evaluation and description of the epidemiological profile, access to treatment and main clinical outcomes of the Brazilian STS patient. A population-based cohort study of 66,825 patients who underwent procedures related to STS treatment registered in the Brazilian public health system (Sistema Único de Saúde, SUS) databases. Median age was 57 years, 30% of them older than 65 years and 50.7% of the cohort was female. The majority, 50,383 patients (75.4%), was diagnosed between 2008 and 2015. Most prevalent anatomic sites were upper and lower limbs (12.6%) and the registry of sarcomas without a specific location comprehended 29.7% of the cohort. The majority of patients resided in the Northeast (40.2% of the patients). Surgery was the first treatment modality in 77.7% of the cases. For survival analysis, only patients with stage and histological grade information were included. The 1-, 5- and 10-year survival rate of the patients was, respectively, 75.4% (95% CI = 74.1-76.7%), 43.4% (95% CI = 41.5-45.5%) and 18.6% (95% CI = 14.8-23.3%).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure1
Figure1
Overall Survival of the Soft-tissue Sarcoma Patient in Brazil (only staged and graded patients).
Figure2
Figure2
Overall survival by gender and age.
Figure 3
Figure 3
Compared Survival by Type of First Treatment between Full Cohort and Only Staged Patients (Above: Full cohort with 66,852 patients. Below: Sub-cohort with 4980 staged patients).
Figure 4
Figure 4
Overall Survival by Clinical Stage.
Figure 5
Figure 5
Study design. 1Mortality Information Systems (SIM), 2Outpatient Information System (SIA/SUS), 3Hospital Information System (SIH/SUS).
See this image and copyright information in PMC

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