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Multicenter Study
. 2022 Jan 1;117(1):189-192.
doi: 10.14309/ajg.0000000000001564.

Increasing Incidence of Cirrhosis Over the Past 2 Decades Among Children in Ontario, Canada

Mohit Kehar  1 , Rebecca Griffiths  2 , Jennifer A Flemming  1   2   3   4
Affiliations
Multicenter Study

Increasing Incidence of Cirrhosis Over the Past 2 Decades Among Children in Ontario, Canada

Mohit Kehar et al. Am J Gastroenterol. .

Abstract

Introduction: We describe the incidence of cirrhosis in the general pediatric population.

Methods: This is a population-based study using health-care data from Ontario, Canada, between 1997 and 2017. Age-adjusted and sex-adjusted standardized incidence rates were described, and age-period-cohort modeling approach was used to estimate the independent effect of birth cohort.

Results: In total, 2,966 new diagnoses of cirrhosis among children were identified at a median age of 9 years. The incidence rate increased almost 4-fold over the study period (2.7/100,000 person-years in 1997 vs 10.6/100,000 person-years in 2017) with the highest increase seen in children younger than 1 year.

Discussion: In this first population-based study in children, the incidence of cirrhosis has increased dramatically over the past 2 decades.

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References

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