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Review
. 2022 Apr;269(4):2227-2244.
doi: 10.1007/s00415-021-10889-9. Epub 2021 Nov 19.

Measuring social cognition in frontotemporal lobar degeneration: a clinical approach

Maria Antonietta Magno  1 , Elisa Canu  1 , Federica Agosta  1   2   3 , Massimo Filippi  4   5   6   7   8
Affiliations
Review

Measuring social cognition in frontotemporal lobar degeneration: a clinical approach

Maria Antonietta Magno et al. J Neurol. 2022 Apr.

Abstract

Alterations in social cognition, a broad term indicating our ability to understand others and adapt our behavior accordingly, have been the focus of growing attention in the past years. Some neurological conditions, such as those belonging to the frontotemporal lobar degeneration (FTLD) spectrum, are associated to varying degrees with social cognition deficits, encompassing problems with theory of mind (ToM), empathy, perception of social stimuli, and social behavior. In this review, we outline a clinical framework for the evaluation of social cognition and discuss its role in the assessment of patients affected by a range of FTLD conditions.

Keywords: Empathy; Frontotemporal degeneration; Social behavior; Social cognition; Social perception; Theory of mind.

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References

    1. Henry JD, von Hippel W, Molenberghs P, Lee T, Sachdev PS (2016) Clinical assessment of social cognitive function in neurological disorders. Nat Rev Neurol 12(1):28–39. https://doi.org/10.1038/nrneurol.2015.229 - DOI - PubMed
    1. Rascovsky K, Hodges JR, Knopman D, Mendez MF, Kramer JH, Neuhaus J, van Swieten JC, Seelaar H, Dopper EG, Onyike CU, Hillis AE, Josephs KA, Boeve BF, Kertesz A, Seeley WW, Rankin KP, Johnson JK, Gorno-Tempini ML, Rosen H, Prioleau-Latham CE, Lee A, Kipps CM, Lillo P, Piguet O, Rohrer JD, Rossor MN, Warren JD, Fox NC, Galasko D, Salmon DP, Black SE, Mesulam M, Weintraub S, Dickerson BC, Diehl-Schmid J, Pasquier F, Deramecourt V, Lebert F, Pijnenburg Y, Chow TW, Manes F, Grafman J, Cappa SF, Freedman M, Grossman M, Miller BL (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134(Pt 9):2456–2477. https://doi.org/10.1093/brain/awr179 - DOI - PubMed - PMC
    1. Premack D, Woodruff G (1978) Does the chimpanzee have a theory of mind? Behav Brain Sci 1(4):515–526 - DOI
    1. Fletcher PC, Happe F, Frith U, Baker SC, Dolan RJ, Frackowiak RS, Frith CD (1995) Other minds in the brain: a functional imaging study of “theory of mind” in story comprehension. Cognition 57(2):109–128. https://doi.org/10.1016/0010-0277(95)00692-r - DOI - PubMed
    1. Shamay-Tsoory SG, Harari H, Aharon-Peretz J, Levkovitz Y (2010) The role of the orbitofrontal cortex in affective theory of mind deficits in criminal offenders with psychopathic tendencies. Cortex 46(5):668–677. https://doi.org/10.1016/j.cortex.2009.04.008 - DOI - PubMed

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