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. 2021 Nov;172(1):77-80.
doi: 10.1007/s10517-021-05335-9. Epub 2021 Nov 19.

Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma

E V Inzhevatkin  1   2 , A V Baron  3 , M B Volkova  4 , N G Maksimov  5 , N K Golubenko  6 , M V Loshkareva  7 , A P Puzyr'  7   3 , N O Ronzhin  3 , V S Bondar  3
Affiliations

Biodistribution of Detonation Synthesis Nanodiamonds in Mice after Intravenous Administration and Some Biochemical Changes in Blood Plasma

E V Inzhevatkin et al. Bull Exp Biol Med. 2021 Nov.

Abstract

Biodistribution of nanodiamonds in mice after intravenous administration, activities of AST and ALT, and the level of bilirubin in the blood plasma were studied in 2.5 h and 10, 35, and 97 days after injection of nanodiamonds. In 2.5 h after intravenous injection, nanodiamonds mainly accumulate in the lungs and liver. Then, redistribution of nanodiamonds from all organs to the liver was observed. Activities of AST and ALT and the level of bilirubin in the blood increased after 2.5 h and then decreased to the initial values.

Keywords: EPR-spectrometry; biochemical changes in blood plasma; biodistribution; detonation synthesis nanodiamonds; intravenous administration.

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References

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