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. 1987 Dec 4;238(4832):1411-3.
doi: 10.1126/science.3479843.

The gene for familial polyposis coli maps to the long arm of chromosome 5

M Leppert  1 , M Dobbs, P Scambler, P O'Connell, Y Nakamura, D Stauffer, S Woodward, R Burt, J Hughes, E Gardner, et al.
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The gene for familial polyposis coli maps to the long arm of chromosome 5

M Leppert et al. Science. .

Abstract

The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.

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