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Review
. 2022 Jan:69:126887.
doi: 10.1016/j.jtemb.2021.126887. Epub 2021 Oct 29.

Vanadium as potential therapeutic agent for COVID-19: A focus on its antiviral, antiinflamatory, and antihyperglycemic effects

Sabina Semiz  1
Affiliations
Review

Vanadium as potential therapeutic agent for COVID-19: A focus on its antiviral, antiinflamatory, and antihyperglycemic effects

Sabina Semiz. J Trace Elem Med Biol. 2022 Jan.

Abstract

An increasing evidence suggests that vanadium compounds are novel potential drugs in the treatment of diabetes, atherosclerosis, and cancer. Vanadium has also demonstrated activities against RNA viruses and is a promising candidate for treating acute respiratory diseases. The antidiabetic, antihypertensive, lipid-lowering, cardioprotective, antineoplastic, antiviral, and other potential effects of vanadium are summarized here. Given the beneficial antihyperglycemic and antiinflammatory effects as well as the potential mechanistic link between the COVID-19 and diabetes, vanadium compounds could be considered as a complement to the prescribed treatment of COVID-19. Thus, further clinical trials are warranted to confirm these favorable effects of vanadium treatment in COVID-19 patients, which appear not to be studied yet.

Keywords: COVID-19; Diabetes mellitus; Hyperglycemia; Inflammation; Insulin sensitivity; SARS-CoV-2 coronavirus; Vanadium.

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Conflict of interest statement

I wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

Figures

Fig. 1
Fig. 1
Chemical structures of: A. Vanadyl sulfate; B. Sodium orthovanadate; C. Peroxovanadium complex; D. Bis(maltolato)oxovanadium(IV) (BMOV), R = CH3, and bis(ethylmaltolato)oxovanadium(IV) (BEOV), R = C2H5.
See this image and copyright information in PMC

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