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Review
. 2022 Jan;32(1):113-130.
doi: 10.1016/j.giec.2021.08.007.

Endoscopic Management and Surgical Considerations for Familial Adenomatous Polyposis

Peter P Stanich  1 , Brian Sullivan  2 , Alex C Kim  3 , Matthew F Kalady  4
Affiliations
Review

Endoscopic Management and Surgical Considerations for Familial Adenomatous Polyposis

Peter P Stanich et al. Gastrointest Endosc Clin N Am. 2022 Jan.

Abstract

Familial adenomatous polyposis (FAP) is the development of many adenomatous colorectal polyps. Colonoscopy is recommended to start at age 10 to 12 years at intervals of 1 to 2 years. Colectomy is clearly indicated for malignancy or significant colorectal symptoms. After colectomy, endoscopic surveillance is still critical. Duodenal and gastric polyposis is also found in almost all patients with FAP. Screening with upper endoscopy and ampullary visualization is recommended, generally determined by age and staging of duodenal polyposis, but guidelines are increasingly factoring in ampullary and gastric manifestations. Surgical management of malignancy or advanced upper tract manifestations is needed.

Keywords: Adenomatous polyposis coli; Colonic neoplasms; Disease management; Duodenal neoplasms; Genetic predisposition to disease.

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