Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Aug-Sep;18(7):387-392.
doi: 10.1016/j.reumae.2021.05.003. Epub 2021 Nov 17.

Psoriatic arthritis: interaction between cardiometabolic diseases and inflammatory burden of the disease

José Andrés Lorenzo Martín  1 , Estefanía Pardo Campo  2 , Marina Pino Martinez  2 , María Colazo Burlato  3 , Manuel Rubén Queiro Silva  2
Affiliations
Free article

Psoriatic arthritis: interaction between cardiometabolic diseases and inflammatory burden of the disease

José Andrés Lorenzo Martín et al. Reumatol Clin (Engl Ed). 2022 Aug-Sep.
Free article

Abstract

Background and objetives: Psoriatic arthritis is accompained by several cardiometabolic comorbidities. Obesity causes a low-grade systemic inflammation and is a negative predictor of treatment response. We wanted to evaluate if there are interactions between metabolic status, inflammatory parameters and disease activity; and whether metabolic or cardiovascular diseases have any association with the reduction of the inflammatory burden by treating the psoriatic arthritis.

Material and methods: We have carried out a cross-sectional descriptive study of 160 patients with psoriatic arthritis. Sociodemographic, clinical and analytical variables were collected, as well as the presence of dactylitis and enthesitis; and HAQ, DAPSA and Minimal Disease Activity criteria. Chi-square test and the H of Kruskall Wallis were used to carry out comparisons, considering P < .05 as statistically significant. To establish correlations, Pearson correlation coefficient was used.

Results: BMI and waist circumference correlate with CRP and ESR (significance: < .05) although the correlation strenght is low (Pearson <.4), but there is no such relationship with DAPSA or meeting MDA criteria. Using biologic therapies is associated with a lower prevalence of cardiovascular events (P = 0.047; OR: 0.12, 95% CI: 0.01-0.9) and enthesitis (P = .008; OR: 0.3, CI 95%: 0.16-0.56); and normal levels of CRP (P = .029; OR: 0.25, 95% CI: 0.07-0.87) and ESR (P = 0.024; OR: 0.36, 95% CI: 0.16-0.82) when comparing to conventional therapies.

Discussion and conclusions: Anti-TNFα treatment could reduce cardiovascular risk in patients with psoriatic arthritis. There may be higher levels of CRP and ESR in obese individuals without this necessarily implying higher disease activity.

Keywords: Anti-TNFα; Artritis psoriásica; Cardiovascular disease; Enfermedad cardiovascular; Enfermedad metabólica; Inflamación; Inflammation; Metabolic disease; Psoriatic arthritis.

PubMed Disclaimer

MeSH terms