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Review
. 2021 Nov 3:14:763610.
doi: 10.3389/fnmol.2021.763610. eCollection 2021.

Non-Coding RNAs in Glioma Microenvironment and Angiogenesis

Dongxue Li  1   2 , Zhe Zhang  3 , Chengyu Xia  2 , Chaoshi Niu  2 , Wenchao Zhou  1   4
Affiliations
Review

Non-Coding RNAs in Glioma Microenvironment and Angiogenesis

Dongxue Li et al. Front Mol Neurosci. .

Abstract

Glioma, especially glioblastoma, is the most common and lethal brain tumor. In line with the complicated vascularization processes and the strong intratumoral heterogeneity, tumor-associated blood vessels in glioma are regulated by multiple types of cells through a variety of molecular mechanisms. Components of the tumor microenvironment, including tumor cells and tumor-associated stromata, produce various types of molecular mediators to regulate glioma angiogenesis. As critical regulatory molecules, non-coding RNAs (ncRNAs) inside cells or secreted to the tumor microenvironment play essential roles in glioma angiogenesis. In this review, we briefly summarize recent studies about the production, delivery, and functions of ncRNAs in the tumor microenvironment, as well as the molecular mechanisms underlying the regulation of angiogenesis by ncRNAs. We also discuss the ncRNA-based therapeutic strategies in the anti-angiogenic therapy for glioma treatment.

Keywords: anti-angiogenic therapy; glioblastoma; non-coding RNAs; tumor microenvironment; tumor vascularization.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Diverse types of intercellular communications mediate the regulatory effects of ncRNAs on glioma angiogenesis in the tumor microenvironment. (A) The distribution and delivery of ncRNAs within the glioma microenvironment. (B) Delivery of ncRNAs from donor to recipient cells through the small EVs and medium/large EVs. (C) Transmission of ncRNAs between adjacent cells through GJIC based on gap junctions and channels. (D) ncRNA regulation of soluble factors that mediate the interaction between donor and recipient cells.
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