Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Dec;79(6):1189-98.

Nonrandom chromosomal changes in human solid tumors: application of an improved culture method

J R Teyssier  1
Affiliations
  • PMID: 3480370

Nonrandom chromosomal changes in human solid tumors: application of an improved culture method

J R Teyssier. J Natl Cancer Inst. 1987 Dec.

Abstract

A cytogenetic study was performed on 48 primary human benign, borderline malignant, and malignant solid tumors from more than 10 different tissues. An improved cell culture method using an extracellular matrix substrate and a polyvalent serum-free medium was applied, which ensured a success rate of about 68%. The results disclosed a nonrandom involvement of chromosomes 1, 3, and 7 (especially duplication of chromosome 7) in numerical changes and a clustering of breakpoints on chromosomes 1, 3, 7, and 11. These data indicate that some chromosomal changes are shared by various types of tumors, suggesting some common genetic clonal evolution pathways.

PubMed Disclaimer

Publication types