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. 2021 Nov 5:12:756408.
doi: 10.3389/fmicb.2021.756408. eCollection 2021.

The Membrane-Water Partition Coefficients of Antifungal, but Not Antibacterial, Membrane-Active Compounds Are Similar

Pavel E Volynsky  1 , Alexandra I Smirnova  2   3 , Sergey A Akimov  4 , Svyatoslav S Sokolov  2 , Fedor F Severin  2
Affiliations

The Membrane-Water Partition Coefficients of Antifungal, but Not Antibacterial, Membrane-Active Compounds Are Similar

Pavel E Volynsky et al. Front Microbiol. .
No abstract available

Keywords: antibacterial; antifungal; membrane; pore; sterol.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) sterols protect membrane against pore formation caused by lysolipids and similar compounds. (B) the water-octanol (WAT-OCT) and the octanol-cyclohexane (OCT-CHX) change in energy of the compounds with antibacterial (AB, red), antifungal (AF, blue), and the dual activity (AB, AF, green). See text for details.
See this image and copyright information in PMC

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