Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Oct 14:12:721344.
doi: 10.3389/fimmu.2021.721344. eCollection 2021.

Commentary: PIRs Mediate Innate Myeloid Cell Memory to Nonself MHC Molecules

Zhenlong Cai  1 , Rui Xing  2 , Jing Liu  3 , Feiyue Xing  1
Affiliations
Comment

Commentary: PIRs Mediate Innate Myeloid Cell Memory to Nonself MHC Molecules

Zhenlong Cai et al. Front Immunol. .
No abstract available

Keywords: Ly49; MHC-1; PIR-A; differentiation; specific innate immune memory.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Formation and interaction of non-specific or specific innate immune memory and adaptive immune memory cells. (a) Innate immune cells can form non-specific memories by pattern recognition receptor (PRR) binding to pathogen-associated molecular patterns (PAMPs) from the extracellular environment, resulting in a rapid response to the same or similar antigens via epigenetic modification, such as H3K4me1, H3K4me3, and H3K9me2, and metabolic reprogramming, such as enhanced glycolysis and cholesterol synthesis. Moreover, during the secondary infection, memory macrophages induced by PRRs can collect and present antigens via cross-presentation to trigger antigen-specific memory formation of NK cells expressing Ly49C/I. (b) In contrast to PRR-mediated non-specific innate immune memory, MHC-I-mediated specific innate immune memory is a “cellular interaction-dependent” mechanism due to its dependence on MHC-I expressed by all nucleated cells, playing a more important role in graft rejection and killing infected cells. (c) Similarly, adaptive immune memory is also characterized by a “cell-dependent” manner, requiring antigen-presenting cells (APCs) to provide MHC-I/II or FcγR initial signaling to prime T cells and B cells. (d) The main differences between MHC-I or PRR-mediated innate immune cell memory and adaptive immune cell memory are concisely featured.
See this image and copyright information in PMC

Comment on

  • PIRs mediate innate myeloid cell memory to nonself MHC molecules.
    Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, Friday AJ, Williams AL, Sun T, Chen J, Chen W, Mortin-Toth S, Danska JS, Wiebe C, Nickerson P, Li T, Mathews LR, Turnquist HR, Nicotra ML, Gingras S, Takayama E, Kubagawa H, Shlomchik MJ, Oberbarnscheidt MH, Li XC, Lakkis FG. Dai H, et al. Science. 2020 Jun 5;368(6495):1122-1127. doi: 10.1126/science.aax4040. Epub 2020 May 7. Science. 2020. PMID: 32381589 Free PMC article.

References

    1. Theisen DJ, Davidson JT, Briseno CG, Gargaro M, Lauron EJ, Wang Q, et al. . WDFY4 is Required for Cross-Presentation in Response to Viral and Tumor Antigens. Science (2018) 362(6415):694–9. doi: 10.1126/science.aat5030 - DOI - PMC - PubMed
    1. Ataide MA, Komander K, Knopper K, Peters AE, Wu H, Eickhoff S, et al. . BATF3 Programs CD8(+) T Cell Memory. Nat Immunol (2020) 21(11):1397–407. doi: 10.1038/s41590-020-0786-2 - DOI - PubMed
    1. Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, et al. . Trained Immunity: A Program of Innate Immune Memory in Health and Disease. Science (2016) 352(6284):aaf1098. doi: 10.1126/science.aaf1098 - DOI - PMC - PubMed
    1. Dai H, Lan P, Zhao D, Abou-Daya K, Liu W, Chen W, et al. . PIRs Mediate Innate Myeloid Cell Memory to Nonself MHC Molecules. Science (2020) 368(6495):1122–7. doi: 10.1126/science.aax4040 - DOI - PMC - PubMed
    1. Wight A, Parsons BD, Rahim MMA, Makrigiannis AP. A Central Role for Ly49 Receptors in NK Cell Memory. J Immunol (2020) 204(11):2867–75. doi: 10.4049/jimmunol.2000196 - DOI - PubMed

Publication types

MeSH terms

Substances