Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Aug 17:34:38-41.
doi: 10.1016/j.mmcr.2021.08.004. eCollection 2021 Dec.

Successful management of Aspergillus infection of an open window thoracostomy with topical liposomal amphotericin B

Alexis Legault-Dupuis  1 , France-Emilie Roy  1 , Isabelle Giroux  1 , Michelle Bernard-Genest  1 , Florence Cote  1 , Anne-Sophie Laliberte  1
Affiliations
Case Reports

Successful management of Aspergillus infection of an open window thoracostomy with topical liposomal amphotericin B

Alexis Legault-Dupuis et al. Med Mycol Case Rep. .

Abstract

We present the case of a previously healthy 54-year-old man who was hospitalized for an Aspergillus fumigatus infection of an open window thoracotomy. Patient was successfully treated for 8 consecutives weeks with daily topical pleural liposomal amphotericine B administered by soaked gauzes combined with systemic therapy.

Keywords: Aspergillus; Empyema; Open window thoracotomy; Pleural antifungal therapy.

PubMed Disclaimer

Conflict of interest statement

There are none.

Figures

Fig. 1
Fig. 1
Right pleuroscopy: Parietal pleura within the right chest cavity with macroscopic fungus disease (red arrows). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2
Fig. 2
Computed tomography (CT) scan of the chest before treatment: Right thoracic window (blue arrow), Pleural thickening (red arrow) caused by the fungus and inflammation, Right lung parenchyma (yellow arrow). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3
Fig. 3
Computed tomography (CT) scan of the chest after treatment: Right thoracic window (blue arrow), Reduced pleural thickening (red arrow), normal right lung parenchyma (yellow arrow). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Abraeu I., Guedes M., Duro R., et al. Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: the challenge of an optimal therapeutic approach. Medical Mycology Case Reports. 2020;28:4–7. - PMC - PubMed
    1. Meredith H., Cogan B., McLauglin B. Pleural aspergillosis Am.J Roentgeol. 1978;130:164–166. - PubMed
    1. Almuhareb A., Habib Z. Management of Aspergillus pleural empyema with combined systemic and intrapleural antifungal therapy in a pediatric patient: case report. J Infect Public Health. 2018 Mar-Apr;11(2):280–282. - PubMed
    1. Bonatti H., Lass-Floerl C., Angerer K., Singh N., Lechner M., Stelzmueller I., Singh R., Schmid T., Geltner C. Successful management of postpneumonectomy Aspergillus pleural empyema by combined surgical and anti-fungal treatment with voriconazole and caspofungin. Mycoses. 2010;53(5):448–454. - PubMed
    1. Purohit M., Guleri A., Zacharias J. Salvage therapy with topical antifungal for Aspergillus fumigatus empyema complicating extrapleural pneumonectomy. Interact. Cardiovasc. Thorac. Surg. 2012;15(3):518–519. - PMC - PubMed

Publication types

LinkOut - more resources