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. 2021 Oct;10(10):3020-3029.
doi: 10.21037/gs-21-611.

A systematic review and meta-analysis: value of ultrasound-guided vacuum-assisted biopsy in the diagnosis and treatment of breast lesions

Weifeng Lu #  1   2 , Lili Tu #  2   3 , Danxuan Xie  2   4 , Fu Yao  2   4 , Li Lin  2   4 , Ying Li  2   4 , Dexin Li  2   5 , Chengjin Mou  2   4
Affiliations

A systematic review and meta-analysis: value of ultrasound-guided vacuum-assisted biopsy in the diagnosis and treatment of breast lesions

Weifeng Lu et al. Gland Surg. 2021 Oct.

Abstract

Background: In recent years, according to global statistics, breast cancer is the main disease affecting women. Ultrasound-guided vacuum-assisted biopsy (VAB) has become a frequently used method for breast cancer detection because of its accuracy, simplicity, and fewer complications.

Methods: In PubMed, Medline, EMbase and Cochrane central register of controlled trials, the retrieval time was from the establishment of the database to March 2021, and the keywords included breast tumor, breast cancer-related diseases, breast lesions, vacuum-assisted breast biopsy, sensitivity and specificity. Meta-analysis was performed using RevMan5.3 software provided by the Cochrane Collaboration.

Results: A total of 10 articles were included using a random-effects model that pooled the sensitivity, specificity, and other accuracy measures of VAB. The summary receiver operating characteristic (SROC) characteristic curve was used to summarize the overall accuracy. The sensitivity range was 0.94 to 1.00 (mean, 0.981; 95% CI, 0.972-0.987) with a specificity range of 0.87-1.00 (mean, 0.999; 95% CI, 0.997-0.999). The preoperative platelet-lymphocyte ratio (PLR) was 93.84 (95% CI, 41.55-211.95), the neutrophil to lymphocyte ratio (NLR) was 0.05 (95% CI, 0.03-0.09), the sensitivity and specificity of χ2 were 37.10 (P=0.011) and 32.00 (P=0.043), respectively, while those of PLR, NLR, and duration of response (DOR) were 46.98 (P=0.001), 54.92 (P=0.001), and 43.49 (P=0.002), respectively. Differences were considerable.

Discussion: In this meta-analysis, a total of 10 articles were included. VAB is an accurate type of biopsy to detect female breast cancer. The results of the meta-analysis were stable, and VAB had high sensitivity (98%) and specificity (nearly 100%).

Keywords: Breast cancer; meta-analysis; ultrasonic; vacuum-assisted biopsy (VAB).

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/gs-21-611). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Literature retrieval process.
Figure 2
Figure 2
Risk of bias assessment diagram of included articles.
Figure 3
Figure 3
Risk of bias evaluation bar graph of included articles.
Figure 4
Figure 4
Forest plot of sensitivity and specificity to vacuum-assisted biopsy in breast cancer diagnosis.
Figure 5
Figure 5
Summary receiver operating characteristic (SROC) curve of vacuum-assisted biopsy.
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