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Review
. 2021 Nov 4:11:757135.
doi: 10.3389/fonc.2021.757135. eCollection 2021.

The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

Zhigang Li  1 , Qingyu Guo  2 , Jiaxin Zhang  2 , Zitong Fu  2 , Yifei Wang  3 , Tianzhen Wang  2 , Jing Tang  2
Affiliations
Review

The RNA-Binding Motif Protein Family in Cancer: Friend or Foe?

Zhigang Li et al. Front Oncol. .

Abstract

The RNA-binding motif (RBM) proteins are a class of RNA-binding proteins named, containing RNA-recognition motifs (RRMs), RNA-binding domains, and ribonucleoprotein motifs. RBM proteins are involved in RNA metabolism, including splicing, transport, translation, and stability. Many studies have found that aberrant expression and dysregulated function of RBM proteins family members are closely related to the occurrence and development of cancers. This review summarizes the role of RBM proteins family genes in cancers, including their roles in cancer occurrence and cell proliferation, migration, and apoptosis. It is essential to understand the mechanisms of these proteins in tumorigenesis and development, and to identify new therapeutic targets and prognostic markers.

Keywords: RNA binding protein; RNA-binding motif protein; cancer; prognosis; tumorigenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The RBM proteins family can affect gene expression and function by intervening mRNA transport, translation, capping, splicing, and stability. The three colored rectangles represent different exons, black lines represent introns, reddish brown circles represent 5 ‘cap, light blue circles represent RBM family proteins, and green rectangles represent the RRM domain. The central circle is the structure of RBM protein, usually, it has one or more RRMs.
Figure 2
Figure 2
The correlation analysis between RBM proteins family expression and the patient’s prognosis in the TCGA. p < 0.05 was considered statistically significant.
See this image and copyright information in PMC

References

    1. Qin H, Ni H, Liu Y, Yuan Y, Xi T, Li X, et al. . RNA-Binding Proteins in Tumor Progression. J Hematol Oncol (2020) 1(13):90. doi: 10.1186/s13045-020-00927-w - DOI - PMC - PubMed
    1. Sutherland LC, Rintala-Maki ND, White RD, Morin CD. RNA Binding Motif (RBM) Proteins: A Novel Family of Apoptosis Modulators? J Cell Biochem (2005) 1(94):5–24. doi: 10.1002/jcb.20204 - DOI - PubMed
    1. Dreyfuss G, Kim VN, Kataoka N. Messenger-RNA-Binding Proteins and the Messages They Carry. Nat Rev Mol Cell Biol (2002) 3(3):195–205. doi: 10.1038/nrm760 - DOI - PubMed
    1. Lee MS, Henry M, Silver PA. A Protein That Shuttles Between the Nucleus and the Cytoplasm is an Important Mediator of RNA Export. Genes Dev (1996) 10(10):1233–46. doi: 10.1101/gad.10.10.1233 - DOI - PubMed
    1. Jonas K, Calin GA, Pichler M. RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer. Int J Mol Sci (2020) 21(8):2969. doi: 10.3390/ijms21082969 - DOI - PMC - PubMed

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