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. 2021 Nov 5:8:771022.
doi: 10.3389/fcvm.2021.771022. eCollection 2021.

Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort

Damien Mandry  1   2 , Nicolas Girerd  3   4   5 , Zohra Lamiral  5 , Olivier Huttin  3   4 , Laura Filippetti  4 , Emilien Micard  5 , Marie-Paule Bernadette Ncho Mottoh  4 , Philip Böhme  6 , Denis Chemla  7   8 , Faïez Zannad  3   4   5 , Patrick Rossignol  3   5   9 , Pierre-Yves Marie  3   10
Affiliations

Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort

Damien Mandry et al. Front Cardiovasc Med. .

Abstract

Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain. Methods: Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling. Results: Sixteen obese subjects had significant weight gain (>7%) during follow-up (WG+), whereas the 59 other individuals did not (WG-). WG+ and WG- exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG-: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min-1 vs. -8.9 ± 11.5 min-1, p = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL-1 vs. WG-: -0.02 ± 0.13 g.mL-1, p = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg-1 vs. WG-: +0.01 ± 0.30 mL mmHg-1, p = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population (p < 0.001, R2 = 0.31). Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.

Keywords: MRI; arterial load; cardiac remodeling; obesity; weight gain.

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Conflict of interest statement

NG, ZL, EM, FZ, and PR were employed by company CHRU-Nancy, INSERM, CIC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Correlation between baseline to follow-up changes in effective arterial elastance (Ea) and in the left ventricular concentric remodeling (CR) index in the overall population of obese subjects.
See this image and copyright information in PMC

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