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Case Reports
. 2021 Oct 25:5:33.
doi: 10.21037/acr-20-168. eCollection 2021.

An adolescent female with a testosterone-secreting ovarian teratoma: a case report

Evangelos Spyridakis  1 , Bryan Weidner  2 , Chi K Nguyen  3 , Berrin Ergun-Longmire  4
Affiliations
Case Reports

An adolescent female with a testosterone-secreting ovarian teratoma: a case report

Evangelos Spyridakis et al. AME Case Rep. .

Abstract

Ovarian neoplasms constitute 1% of childhood tumors. The majority of them are teratomas and usually are asymptomatic or present with paraneoplastic syndromes. Our case is a 16-year-old female who presented with chronic abdominal pain, virilization and oligomenorrhea and found to have a complex cystic mass of the left ovary, more likely cystic teratoma on abdomen and pelvis CT. Further work-up revealed significantly elevated serum total and free testosterone. The patient subsequently underwent left salpingo-oophorectomy confirming the radiological findings. Within two week after surgery, serum testosterone normalized and the patient started having regular menstrual cycles. In summary, ovarian teratomas should be include in the differential diagnosis of abdominal pain and menstrual abnormalities in female adolescents. Further studies are needed to determine the role of ovarian-sparing surgery in this patient population.

Keywords: Teratoma; abdominal pain; case report; testosterone; virilization.

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/acr-20-168). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
CT scan of pelvis showing a 13.6×20.3×31.1 cm mass which contains areas of fat, calcification and fluid.
Figure 2
Figure 2
Gross finding of ovarian mass measuring 21.5×15×10. The exterior surface of the ovary had a smooth grey-white appearance without papillations.
Figure 3
Figure 3
Cartilage and respiratory epithelium of mature cystic teratoma (H&E, ×10).
Figure 4
Figure 4
Skin with appendages of mature cystic teratoma (H&E, ×10).
Figure 5
Figure 5
Ovarian stroma with Leydig cells of mature cystic teratoma (H&E, ×20).
Figure 6
Figure 6
Focus of Leydig cells embedding in ovarian stroma of mature cystic teratoma (H&E, ×40).
See this image and copyright information in PMC

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