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. 2019 Jul 31;2(2):78-83.
doi: 10.1016/j.jimed.2019.07.005. eCollection 2019 May.

Sorafenib plus hepatic arterial infusion chemotherapy with oxaliplatin versus sorafenib alone for advanced hepatocellular carcinoma

Yang Zhao  1 , JiaYing Lai  2 , RunBin Liang  1 , MinKe He  1 , Ming Shi  1
Affiliations

Sorafenib plus hepatic arterial infusion chemotherapy with oxaliplatin versus sorafenib alone for advanced hepatocellular carcinoma

Yang Zhao et al. J Interv Med. .

Erratum in

Abstract

Objective: To compare the efficacy of sorafenib plus hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin to that of sorafenib alone in patients with advanced hepatocellular carcinoma (HCC).

Methods: This was a retrospective, single-center trial. Between April 3, 2017 and July 2, 2018, 104 patients with Child-Pugh A and advanced HCC received either 400 mg of sorafenib orally twice daily plus HAIC with oxaliplatin (oxaliplatin 85 mg/m2, every 3 weeks via repetitive catheterization) (n = 46, soraOXA group) or 400 mg of only sorafenib orally twice daily (n = 58, sorafenib group). Overall survival, progression-free survival, objective response rate, and treatment-related adverse events were compared.

Results: The median overall survival was 9.37 months (95% CI, 7.05-11.68) in the soraOXA group versus 4.8 months (95% CI, 2.98-6.62) in the sorafenib group (HR 0.46 [95% CI, 0.29-0.72]; P < 0.001). The soraOXA group also showed a higher objective response rate (16 [34.8%] vs 1 [1.7%]; P < 0.001) and a longer progression-free survival rate (5.5 months [95% CI, 2.32-8.68] vs 2.4 months [95% CI, 1.65-3.15], HR 0.54 [95% CI, 0.36-0.81], P = 0.003) than the sorafenib group. There was no significant difference in the overall incidence of any grade adverse events, grade 3/4 adverse events, serious adverse events, or incidence of treatment termination due to adverse events between the two groups.

Conclusion: Compared with sorafenib alone, sorafenib plus HAIC with oxaliplatin showed favorable treatment outcomes in patients with advanced HCC. The merits of this approach need to be established with a prospective trial.

Keywords: Barcelona clinic liver cancer stage C; Hepatic arterial infusion chemotherapy; Hepatocellular carcinoma; Oxaliplatin; Sorafenib.

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Figures

Fig. 1
Fig. 1
Patients selection flow. HCC, hepatocellular carcinoma. HAIC, hepatic arterial infusion chemotherapy. OXA, oxaliplatin. SoraOXA group = sorafenib plus hepatic arterial infusion of oxaliplatin. Sorafenib group = Sorafenib monotherapy group.
Fig. 2
Fig. 2
Kaplan-Meier curves for overall survival (A), and progression-free survival (B). SoraOXA group = sorafenib plus hepatic arterial infusion of oxaliplatin. Sorafenib group = Sorafenib monotherapy group.
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