Evolution, progress, and prospects of research on transjugular intrahepatic portosystemic shunt applications

Abstract

Transjugular intrahepatic portosystemic shun (TIPS) is an effective procedure for the treatment of portal hypertension complications such as esophagogastric variceal bleeding and refractory ascites. To date, its use by many experts and scholars at home and abroad has benefitted countless patients. In order to further promote the development and innovation of TIPS in China, this paper briefly reviews the development process of TIPS at home and abroad, objectively analyzes the bottlenecks and breakthrough achievements in the development of TIPS, and discusses the application status and research progress of TIPS technology for different indications. Finally, we provide an outlook about the development and application of TIPS in China.

Keywords: Application situation; Prospect; Research progress; TIPS.

Fig. 1

The team of Professor Ke Xu completed the first TIPS operation of China.

Fig. 2

1A: one case of significantly reducing hepatic pleural effusion after TIPS; 1B: early TIPS prolongs survival time in patients with recurrent ascites. Reproduce from Ref. [19]. 2A: Budd-Chiari is considered as an indication of TIPS in AASLD. Reproduce from Ref. [13]; 2B: One Budd-Chiari patient with intractable ascites, and ascites decreased significantly after TIPS. 3A: One patient with portal vein thrombosis/cavernous transformation still have gastrointestinal bleeding after splenectomy and endoscopic ligation. After portal vein thrombolysis and TIPS treatment, gastrointestinal bleeding disappeared; 3B: Relevant research shows that TIPS should be considered a safe and feasible alternative therapy for patients with chronic portal vein thrombosis. Reproduce from Ref. [28].