Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 21;4(3):143-148.
doi: 10.1016/j.jimed.2021.05.005. eCollection 2021 Aug.

Value of low-dose and optimized-length computed tomography (CT) scan in CT-guided percutaneous transthoracic needle biopsy of pulmonary nodules

Hui Yuan  1   2 , Da Li  1   2 , Yan Zhang  1   2 , Xiaozhen Xie  1   2 , Lujun Shen  1   2
Affiliations

Value of low-dose and optimized-length computed tomography (CT) scan in CT-guided percutaneous transthoracic needle biopsy of pulmonary nodules

Hui Yuan et al. J Interv Med. .

Abstract

Objective: To investigate the value of application of low-dose and optimized length CT scan on puncture results, complications and patients' radiation dosage during CT-guided percutaneous biopsy of pulmonary nodules (PTNB).

Methods: A total of 231 patients with PTNB under CT guidance were collected. Low dose scanning utilized tube current of 20 mA as compared with 40 mA in conventional dosage. Optimized length in CT is defined as intentionally narrowing the range of CT scanning just to cover 25 mm (5 layers) around the target layer during needle adjustment. According to whether low-dose scans and optimized length scans techniques were utilized, patients were divided into three groups: conventional group (conventional sequence + no optimization), optimized length group (conventional sequence + optimized length), and low-dose optimized length group (low dose sequence + optimized length). The ED (effective dose), the DLP (dose length product), the average CTDIvol (Volume CT dose index), total milliampere second between subgroups were compared.

Results: Compared with the conventional group, ED, intraoperative guidance DLP, total milliseconds and operation time in the optimized length group were reduced by 18.2% (P=0.01), 37% (P=0.003), 17.5% (P=0.013) and 13.3% (P=0.021) respectively. Compared with the optimized length group, the ED was reduced by 87%, preoperative positioning, intraoperative guidance and postoperative review DLP were also reduced by 88%, total milliampere second was reduced by 79%, with an average CTDIvol was reduced by 86%, in the low-dose optimized length group (P<0.001 for all).

Conclusion: Optimizing the length during CT scanning can effectively reduce the intraoperative radiation dose and reduce the operation time compared with conventional plan; low-dose and optimized length CT scan can further reduce the total radiation dose compared with optimized length group with no differences on intraoperative complications, biopsy results and operation time.

Keywords: CT guided; Low dose; Lung biopsy; Optimized scan; Radiation dose.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. Acknowledgements This work was supported by grants from National Natural Science Foundation of China (No. 81801804).

Figures

Fig. 1
Fig. 1
A and C are pictures during CT guidance before and after puncture in the optimized length group, B and D are during CT guidance before and after puncture in the low-dose optimization length group. Both groups of pictures can clearly show the puncture needle and the lesion. The relationship of normal lung structure can also be clearly shown for postoperative review for identification of potential complications, such as needle bleeding.
Fig. 2
Fig. 2
A-D showed that the quality of CT pictures in low-dose optimization length group meet the demand of biopsy for lung lesions in different lobes and patients in different position.
Fig. 3
Fig. 3
Comparison of the distribution of DLP among the three groups in terms of preoperative positioning, intraoperative guidance and postoperative review.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fabrizio F.P., Sparaneo A., Centra F. Methylation density pattern of KEAP1 gene in lung cancer cell lines detected by quantitative methylation specific PCR and pyrosequencing. Int J Mol Sci. 2019;20:2697. - PMC - PubMed
    1. Jamshidi N., Huang D., Abtin F.G. Genomic adequacy from solid tumor core needle biopsies of ex vivo tissue and in vivo lung masses: prospective study. Radiology. 2017;282:903–912. - PubMed
    1. Mendoza D.P., Dagogo-Jack I., Chen T. Imaging characteristics of BRAF-mutant non-small cell lung cancer by functional class. Lung Canc. 2019;129:80–84. - PubMed
    1. Lee C., Guichet P.L., Abtin F. Percutaneous lung biopsy in the molecular profiling era: a survey of current practices. J Thorac Imag. 2017;32:63–67. - PubMed
    1. Tavare A.N., Hare S.S., Miller F.N.A. A survey of UK percutaneous lung biopsy practice: current practices in the era of early detection, oncogenetic profiling, and targeted treatments. Clin Radiol. 2018;73:800–809. - PubMed

LinkOut - more resources