Adaptive designs for clinical trials have potential advantages, but statistical challenges lurk!

S N Lo^{1

2}, J F Thompson^{1

2}

Affiliations

¹ Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
² Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

Comment

S N Lo et al. Br J Dermatol. 2022 Feb.

. 2022 Feb;186(2):205-206.

doi: 10.1111/bjd.20828. Epub 2021 Nov 22.

S N Lo^{1

2}, J F Thompson^{1

2}

¹ Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
² Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.

No abstract available

Comment on

Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT).
Cro S, Cornelius VR, Pink AE, Wilson R, Pushpa-Rajah A, Patel P, Abdul-Wahab A, August S, Azad J, Becher G, Chapman A, Dunnil G, Ferguson AD, Fogo A, Ghaffar SA, Ingram JR, Kavakleiva S, Ladoyanni E, Leman JA, Macbeth AE, Makrygeoegou A, Parslew R, Ryan AJ, Sharma A, Shipman AR, Sinclair C, Wachsmuth R, Woolf RT, Wright A, McAteer H, Barker JNWN, Burden AD, Griffiths CEM, Reynolds NJ, Warren RB, Lachmann HJ, Capon F, Smith CH; APRICOT Study Group. Cro S, et al. Br J Dermatol. 2021 Aug 19;186(2):245-56. doi: 10.1111/bjd.20653. Online ahead of print. Br J Dermatol. 2021. PMID: 34411292 Free PMC article.

1. Pallmann P, Bedding AW, Choodari-Oskooei B et al. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Med 2018; 16:29.
1. Chow SC, Chang M, Pong A. Statistical consideration of adaptive methods in clinical development. J Biopharm Stat 2005; 15:575-91.
1. Cro S, Cornelius VR, Pink AE et al. Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT). Br J Dermatol 2022; 186:245-56.