Global, regional and national burden of disease attributable to 19 selected occupational risk factors for 183 countries, 2000-2016: A systematic analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury
- PMID: 34806754
- PMCID: PMC9045235
- DOI: 10.5271/sjweh.4001
Global, regional and national burden of disease attributable to 19 selected occupational risk factors for 183 countries, 2000-2016: A systematic analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury
Abstract
Objectives: We provide a brief introduction to the objectives, data, methods and results of the World Health Organization (WHO)/International Labor Organization (ILO) Joint Estimates of the Work-related Burden of Disease and Injury (WHO/ILO Joint Estimates), which estimated the burden attributable to 19 selected occupational risk factors.
Methods: The WHO/ILO Joint Estimates were produced within the global Comparative Risk Assessment framework, which attributes the burden of one specific health outcome (ie, disease/injury) to a specific occupational risk factor. For 39 established occupational risk factor-health outcome pairs, estimates are produced using population attributable fractions (PAF) from recent burden of disease estimates. For two additional pairs, PAF are calculated from new databases of exposure and risk ratios produced in WHO/ILO systematic reviews. Attributable disease burdens were estimated by applying the PAF to total disease burdens.
Results: Globally in 2016, it is estimated that 1.88 [95% uncertainty range (UR) 1.84-1.92] million deaths and 89.72 (95% UR 88.61-90.83) million disability-adjusted life years were attributable to the 19 selected occupational risk factors and their health outcomes. A disproportionately large work-related burden of disease is observed in the WHO African Region (for disability-adjusted life years), South-East Asia Region, and Western Pacific Region (for deaths), males and older age groups.
Conclusions: The WHO/ILO Joint Estimates can be used for global monitoring of exposure to occupational risk factors and work-related burden of disease and to identify, plan, cost, implement and evaluate policies, programs and actions to prevent exposure to occupational risk factors and their associated burden.
Conflict of interest statement
Authors declare no conflicts of interest.
Figures




Similar articles
-
Global, regional and national burdens of non-melanoma skin cancer attributable to occupational exposure to solar ultraviolet radiation for 183 countries, 2000-2019: A systematic analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.Environ Int. 2023 Nov;181:108226. doi: 10.1016/j.envint.2023.108226. Epub 2023 Nov 8. Environ Int. 2023. PMID: 37945424
-
The effect of occupational exposure to welding fumes on trachea, bronchus, and lung cancer: A supplementary analysis of regular occupational exposure and of occasional occupational exposure based on the systematic review and meta-analysis from the WHO/ILO Joint estimates of the work-related burden of disease and Injury.Environ Int. 2025 Feb;196:109216. doi: 10.1016/j.envint.2024.109216. Epub 2024 Dec 19. Environ Int. 2025. PMID: 39984224
-
The effect of occupational exposure to ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.Environ Int. 2021 May;150:106349. doi: 10.1016/j.envint.2020.106349. Epub 2021 Feb 3. Environ Int. 2021. PMID: 33546919
-
The prevalences and levels of occupational exposure to dusts and/or fibres (silica, asbestos and coal): A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.Environ Int. 2023 Aug;178:107980. doi: 10.1016/j.envint.2023.107980. Epub 2023 May 21. Environ Int. 2023. PMID: 37487377
-
Global, regional, and national burdens of ischemic heart disease and stroke attributable to exposure to long working hours for 194 countries, 2000-2016: A systematic analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.Environ Int. 2021 Sep;154:106595. doi: 10.1016/j.envint.2021.106595. Epub 2021 May 17. Environ Int. 2021. PMID: 34011457 Free PMC article.
Cited by
-
Association of Evening Shifts, Night Shifts, and Consistent Overtime Exceeding 10 Hours per Day with Sudden Cardiac Arrest: A Case-Control Study.J Clin Med. 2024 Sep 12;13(18):5393. doi: 10.3390/jcm13185393. J Clin Med. 2024. PMID: 39336880 Free PMC article.
-
How can Ministries of Health and Labour add the new indicator on work-related diseases to the monitoring system for the United Nations global goals?Ind Health. 2024;62(3):153-160. doi: 10.2486/indhealth.62_300. Ind Health. 2024. PMID: 38825506 Free PMC article. No abstract available.
-
Long Working Hours and the Risk of Glucose Intolerance: A Cohort Study.Int J Environ Res Public Health. 2022 Sep 19;19(18):11831. doi: 10.3390/ijerph191811831. Int J Environ Res Public Health. 2022. PMID: 36142103 Free PMC article.
-
Research topics in occupational medicine, 1990-2022: A text-mining-applied bibliometric study.Scand J Work Environ Health. 2024 Oct 1;50(7):567-576. doi: 10.5271/sjweh.4177. Epub 2024 Jul 6. Scand J Work Environ Health. 2024. PMID: 39292164 Free PMC article.
-
Occupational Risk Factors for Stroke: A Comprehensive Review.J Stroke. 2023 Sep;25(3):327-337. doi: 10.5853/jos.2023.01011. Epub 2023 Sep 26. J Stroke. 2023. PMID: 37813670 Free PMC article. Review.
References
-
- United Nations. Transforming our world:The 2030 agenda for Sustainable Development. United Nations; 2015.
-
- Descatha A, Sembajwe G, Baer M, Boccuni F, Di Tecco C, Duret C, et al. WHO/ILO work-related burden of disease and injury:protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on stroke. Environ Int. 2018;119:366–78. https://doi.org/10.1016/j.envint.2018.06.016. - PubMed
-
- Descatha A, Sembajwe G, Pega F, Ujita Y, Baer M, Boccuni F, et al. The effect of exposure to long working hours on stroke:a systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury. Environ Int. 2020;142:105746. https://doi.org/10.1016/j.envint.2020.105746. - PubMed
-
- Godderis L, Boonen E, Cabrera Martimbianco AL, Delvaux E, Ivanov ID, Lambrechts MC, et al. WHO/ILO work-related burden of disease and injury:Protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on alcohol consumption and alcohol use disorders. Environ Int. 2018;120:22–33. https://doi.org/10.1016/j.envint.2018.07.025. - PubMed
-
- Hulshof CTJ, Colosio C, Daams JG, Ivanov ID, KC P, Kuijer PPFM, et al. WHO/ILO work-related burden of disease and injury:Protocol for systematic reviews of exposure to occupational ergonomic risk factors and of the effect of exposure to occupational ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases. Environ Int. 2019;125:554–66. https://doi.org/10.1016/j.envint.2018.09.053. - PMC - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical