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. 2022 Feb 15;66(2):e0166721.
doi: 10.1128/AAC.01667-21. Epub 2021 Nov 22.

Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010-2019)

Cecilia G Carvalhaes  1 , Helio S Sader  1 , Jennifer M Streit  1 , Mariana Castanheira  1 , Rodrigo E Mendes  1
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Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010-2019)

Cecilia G Carvalhaes et al. Antimicrob Agents Chemother. .

Abstract

Oritavancin displayed potent and stable activity (MIC90 range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (MRSA) and resistant subsets of Enterococcus spp. Daptomycin and linezolid were also active against methicillin-resistant S. aureus and vancomycin-resistant Enterococcus (VRE). Only oritavancin and linezolid remained active against Enterococcus faecium isolates displaying an elevated daptomycin MIC (i.e., 2 to 4 mg/L). Proportions of methicillin-resistant S. aureus and vancomycin-resistant Enterococcus within the respective S. aureus and enterococcal populations decreased over this period.

Keywords: E. faecium; VRE; VanA; VanB; daptomycin resistance; lipoglycopeptides; vancomycin resistance.

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Conflict of interest statement

The authors declare no conflict of interest.

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