Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta-analysis

Estela Kaminagakura^{1

2}, Rubens Nisie Tango³, Danyel Cruz-Perez⁴, Roberta Bonan⁴, Luciana Yamamoto de Almeida⁵, Maria Letícia de Almeida Lança¹, Paulo Bonan⁶, Hélder Martins⁷, Ademar Takahama Jr⁸, Fábio Augusto Ito⁸, Cláudia Malheiros Coutinho-Camillo⁹, Silvia Vanessa Lourenço¹⁰, Taciana Caneppele¹¹, Andrew G Sikora¹², Luiz Paulo Kowalski^{13

14}, Simon Young²

Affiliations

¹ Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
² Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
³ Department of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
⁴ Department of Clinical and Preventive Dentistry, School of Dentistry, Federal University of Pernambuco, Recife, Brazil.
⁵ Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (Unesp), Araraquara, Brazil.
⁶ Department of Clinical and Social Dentistry, School of Dentistry, Federal University of Paraíba, João Pessoa, Brazil.
⁷ Department of Oral Pathology, School of Dentistry, University Federal do Rio Grande do Norte, Natal, Brazil.
⁸ Department of Oral Medicine and Pediatric Dentistry, State University of Londrina, Londrina, Brazil.
⁹ International Research Center, A.C. Camargo Cancer Center, São Paulo, Brazil.
¹⁰ Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
¹¹ Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
¹² Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
¹³ Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil.
¹⁴ Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Centre, São Paulo, Brazil.

PMID: 34808012
DOI: 10.1002/hed.26940

Meta-Analysis

Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta-analysis

Estela Kaminagakura et al. Head Neck. 2022 Feb.

. 2022 Feb;44(2):548-561.

doi: 10.1002/hed.26940. Epub 2021 Nov 22.

Authors

Affiliations

¹ Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
² Department of Oral and Maxillofacial Surgery, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
³ Department of Dental Materials and Prosthodontics, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
⁴ Department of Clinical and Preventive Dentistry, School of Dentistry, Federal University of Pernambuco, Recife, Brazil.
⁵ Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (Unesp), Araraquara, Brazil.
⁶ Department of Clinical and Social Dentistry, School of Dentistry, Federal University of Paraíba, João Pessoa, Brazil.
⁷ Department of Oral Pathology, School of Dentistry, University Federal do Rio Grande do Norte, Natal, Brazil.
⁸ Department of Oral Medicine and Pediatric Dentistry, State University of Londrina, Londrina, Brazil.
⁹ International Research Center, A.C. Camargo Cancer Center, São Paulo, Brazil.
¹⁰ Department of General Pathology, Dental School, University of São Paulo, São Paulo, Brazil.
¹¹ Department of Restorative Dentistry, Institute of Science and Technology, São Paulo State University (Unesp), São José dos Campos, Brazil.
¹² Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
¹³ Department of Head and Neck Surgery, University of São Paulo Medical School, São Paulo, Brazil.
¹⁴ Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Centre, São Paulo, Brazil.

PMID: 34808012
DOI: 10.1002/hed.26940

Abstract

To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10-1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63-0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70-1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.

Keywords: disease-free survival; overall survival; prognosis; relapse; young.

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References

REFERENCES

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Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta-analysis

Affiliations

Oral squamous cell carcinoma outcome in adolescent/young adult: Systematic review and meta-analysis

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical