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Review
. 2021 Dec;11(12):e2431.
doi: 10.1002/brb3.2431. Epub 2021 Nov 22.

Human urinary kallidinogenase combined with edaravone in treating acute ischemic stroke patients: A meta-analysis

Di-Xiao Yang  1 , Yao Li  2 , Dan Yu  3 , Bi Guan  1 , Qian Ming  1 , Yan Li  1 , Li-Qing Chen  3
Affiliations
Review

Human urinary kallidinogenase combined with edaravone in treating acute ischemic stroke patients: A meta-analysis

Di-Xiao Yang et al. Brain Behav. 2021 Dec.

Abstract

Introduction: Several studies have investigated the efficacy of human urinary kallidinogenase (HUK) combined with edaravone (Eda) in acute ischemic stroke (AIS) patients. Our aim was to provide the best available evidence for clinical practice and further research programs for stroke treatment.

Methods: We searched the online database for paper published between January 2015 and April 2021. We calculated weighted mean difference (WMD) or odds risk (OR) and their corresponding 95% confidence interval (95% CI) of reported outcomes between HUK plus Eda and Eda groups for each study. The random-effect models or fixed-effect models were used to pool the analysis.

Results: Thirteen studies with 1242 patients were included. In the pooled analysis, the scores of NIHSS in the HUK plus Eda group were significantly lower than that in patients receiving Eda (WMD = -3.92, 95% CI (-4.82, -3.02), p < .0001). The ADL scores in the HUK plus Eda group were significantly greater than that in patients receiving Eda (WMD = 14.13, 95% CI (10.67, 17.60), p < .0001). Furthermore, HUK plus Eda was associated with a higher rate of total efficacy (OR = 3.97, 95% CI (2.81, 5.59), p < .0001).

Conclusions: HUK combined with Eda provides potential clinical benefits as a treatment for AIS. Further high-quality, large-scale randomized trials are needed to confirm these results.

Keywords: acute ischemic stroke; edaravone; human urinary kallidinogenase; meta-analysis.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of search strategy
FIGURE 2
FIGURE 2
Risk of bias assessment
FIGURE 3
FIGURE 3
(a) Forest plot of NIHSS. (b) Sensitivity analysis of NIHSS
FIGURE 4
FIGURE 4
(a) Forest plot of ADL. (b) Sensitivity analysis of ADL
FIGURE 5
FIGURE 5
(a) Forest plot of total efficacy rate. (b) Sensitivity analysis of total efficacy rate
See this image and copyright information in PMC

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