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. 2021 Dec;27(12):3147-3150.
doi: 10.3201/eid2712.203172.

Incubation Period for Neuroinvasive Toscana Virus Infections

Lison Laroche, Frédéric Jourdain, Nazli Ayhan, Anne-Laure Bañuls, Rémi Charrel, Jorian Prudhomme

Incubation Period for Neuroinvasive Toscana Virus Infections

Lison Laroche et al. Emerg Infect Dis. 2021 Dec.

Abstract

Toscana virus (TOSV) is an emerging pathogen in the Mediterranean area and is neuroinvasive in its most severe form. Basic knowledge on TOSV biology is limited. We conducted a systematic review on travel-related infections to estimate the TOSV incubation period. We estimated the incubation period at 12.1 days.

Keywords: Mediterranean; Phenuiviridae; Phlebovirus; Sandfly fever Naples phlebovirus; Toscana virus; arbovirus; imported infectious diseases; incubation period; meningitis; sand flies; vector-borne infections.

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Figures

Figure 1
Figure 1
Geographic distribution of imported neuroinvasive cases of TOSV (n = 24) and countries of origin of infection. TOSV, Toscana virus.
Figure 2
Figure 2
Cumulative percentage of Toscana virus cases manifesting with neurologic symptoms by a given day under the estimates for the Weibull parametric distribution (n = 24). Red dashed line represents the median estimation of the incubation period. Solid red horizontal line represents the 95% CI of the median. Gray shading indicates the 95% CI of the values.
See this image and copyright information in PMC

References

    1. Depaquit J, Grandadam M, Fouque F, Andry PE, Peyrefitte C. Arthropod-borne viruses transmitted by Phlebotomine sandflies in Europe: a review. Euro Surveill. 2010;15:19507. 10.2807/ese.15.10.19507-en - DOI - PubMed
    1. Ayhan N, Prudhomme J, Laroche L, Bañuls AL, Charrel RN. Broader geographical distribution of toscana virus in the Mediterranean region suggests the existence of larger varieties of sand fly vectors. Microorganisms. 2020;8:e114. 10.3390/microorganisms8010114 - DOI - PMC - PubMed
    1. Charrel RN, Bichaud L, de Lamballerie X. Emergence of Toscana virus in the mediterranean area. World J Virol. 2012;1:135–41. 10.5501/wjv.v1.i5.135 - DOI - PMC - PubMed
    1. Charrel RN, Gallian P, Navarro-Marí JM, Nicoletti L, Papa A, Sánchez-Seco MP, et al. Emergence of Toscana virus in Europe. Emerg Infect Dis. 2005;11:1657–63. 10.3201/eid1111.050869 - DOI - PMC - PubMed
    1. Braito A, Corbisiero R, Corradini S, Marchi B, Sancasciani N, Fiorentini C, et al. Evidence of Toscana virus infections without central nervous system involvement: a serological study. Eur J Epidemiol. 1997;13:761–4. 10.1023/A:1007422103992 - DOI - PubMed

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