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Randomized Controlled Trial
. 2022 Jun;142(6):1749-1752.e4.
doi: 10.1016/j.jid.2021.07.190. Epub 2021 Nov 19.

A Randomized Open-Label Clinical Trial of Lipid-Lowering Therapy in Psoriasis to Reduce Vascular Endothelial Inflammation

Michael S Garshick  1 , Kamelia Drenkova  2 , Tessa J Barrett  2 , Florencia Schlamp  2 , Edward A Fisher  3 , Stuart Katz  4 , Sanja Jelic  5 , Andrea L Neimann  6 , Jose U Scher  7 , James Krueger  8 , Jeffrey S Berger  9
Affiliations
Randomized Controlled Trial

A Randomized Open-Label Clinical Trial of Lipid-Lowering Therapy in Psoriasis to Reduce Vascular Endothelial Inflammation

Michael S Garshick et al. J Invest Dermatol. 2022 Jun.
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

MSG has received personal fees from Abbvie. JUS has served as a consultant for Janssen, Abbvie, Novartis, Sanofi, UCB, and BMS. JK has received grants from Novartis, Pfizer, Amgen, Lilly, Boehringer, Innovaderm, BMS, Janssen, Abbvie, Paraxel, Leo Pharma, Vitae, Akros, Regeneron, Allergan, Novan, Biogen MA, Sienna, UCB, Celgene, Botanix, Incyte, Avillion, and Exicure. He has received personal fees from Novartis, Pfizer, Amgen, Lilly, Boehringer, BiogenIdec, Abbvie, Leo Pharma, Escalier, Valeant, Aurigne, Allergan, Asana, UCB, Sienna, Celgene, Nimbus, Menlo, Aristea, Sanofi, Sun Pharma, Almirall, Arena, and BMS. JSB has grants from the National Institutes of Health/National Heart, Lung, and Blood Institute related to the topic and has served on the advisory board for Amgen and Jannsen.

Figures

Figure 1.
Figure 1.. A 2-week lipid-lowering therapy with atorvastatin reduces vascular endothelial inflammation.
(a) Composite log2 fold change in brachial vein endothelial inflammatory transcript expression in those randomized to atorvastatin (n = 18) or no treatment (n = 10) for 2 weeks. (b) Correlation between atorvastatin-treated patients and composite log2 fold change in brachial vein endothelial inflammatory transcript expression. (c) Percentage change in LDL-C over 2 weeks; colors correspond to <35% or ≥35% reduction in LDL-C. (d) Composite log2 fold change in brachial vein endothelial inflammatory transcript expression stratified by no treatment (n = 10), <35% reduction in LDL-C (n = 6), and ≥35% reduction in LDL-C (n = 12) after atorvastatin treatment.
See this image and copyright information in PMC

Comment in

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