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Meta-Analysis
. 2022 Mar;84(3):418-467.
doi: 10.1016/j.jinf.2021.11.013. Epub 2021 Nov 20.

Efficacy and safety of tocilizumab in hospitalized COVID-19 patients: A systematic review and meta-analysis

Affiliations
Meta-Analysis

Efficacy and safety of tocilizumab in hospitalized COVID-19 patients: A systematic review and meta-analysis

Lili Luo et al. J Infect. 2022 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
Forest plot for the efficacy and safety of tocilizumab in randomized controlled trials. (A) 28–30 days mortality. (B) overall mortality. (C) Progression to mechanical ventilation. (D) Secondary infection. (E) Severe adverse events.
Fig. 1
Fig. 1
Forest plot for the efficacy and safety of tocilizumab in randomized controlled trials. (A) 28–30 days mortality. (B) overall mortality. (C) Progression to mechanical ventilation. (D) Secondary infection. (E) Severe adverse events.
Fig. 2
Fig. 2
Forest plot for the efficacy and safety of tocilizumab in cohort studies. (A) 28–30 days mortality. (B) overall mortality. (C) progression to mechanical ventilation. (D) secondary infection.
Fig. 2
Fig. 2
Forest plot for the efficacy and safety of tocilizumab in cohort studies. (A) 28–30 days mortality. (B) overall mortality. (C) progression to mechanical ventilation. (D) secondary infection.

Comment in

References

    1. Coomes E.A., Haghbayan H. Interleukin-6 in Covid-19: A systematic review and meta-analysis. Rev Med Virol. 2020;30(6):1–9. NovPubMed PMID: 32845568. Pubmed Central PMCID: PMC7460877. Epub 2020/08/28. eng. - PMC - PubMed
    1. Lan S.H., Lai C.C., Huang H.T., Chang S.P., Lu L.C., Hsueh P.R. Tocilizumab for severe COVID-19: a systematic review and meta-analysis. Int J Antimicrob Agents. 2020;56(3) SepPubMed PMID: 32712333. Pubmed Central PMCID: PMC7377685. Epub 2020/07/28. eng. - PMC - PubMed
    1. Tharmarajah E., Buazon A., Patel V., Hannah J., Adas M., Allen V., et al. IL-6 inhibition in the treatment of COVID-19: a meta-analysis and meta-regression. J Infect. 2021 PubMed PMID: 33745918. - PMC - PubMed
    1. Chen C.X., Hu F., Wei J., Yuan L.T., Wen T.M., Gale R.P., et al. Systematic review and meta-analysis of tocilizumab in persons with coronavirus disease-2019 (COVID-19) Leukemia. 2021;35(6):1661–1670. JunPubMed PMID: 34002026. Pubmed Central PMCID: PMC8127467 Mingsight Parmaceuticals Inc. and CStone Pharmaceuticals. Advisor: Antegene Biotech LLC, Medical Director: FFF Enterprises Inc. Partner: AZACA Inc. Board of Directors: RakFond Foundation for Cancer Research Support. Scientific Advisory Board, StemRad Ltd. All other authors declare no competing interests. Epub 2021/05/19. eng. - PMC - PubMed
    1. Group R.C. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021;397(10285):1637–1645. PubMed PMID: 33933206. - PMC - PubMed

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