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Comment
. 2022 Mar;84(3):418-467.
doi: 10.1016/j.jinf.2021.11.012. Epub 2021 Nov 19.

Alpha (B.1.1.7) and Delta (B.1.617.2 - AY.40) SARS-CoV-2 variants present strong neutralization decay at M4 post-vaccination and a faster replication rates than D614G (B.1) lineage

Samuel Lebourgeois  1 , Reyene Menidjel  2 , Houssem Redha Chenane  2 , Valentine Marie Ferré  3 , Gilles Collin  3 , Florence Damond  3 , Romain Coppée  2 , Yazdan Yazdanpanah  4 , Jean-François Timsit  5 , Nadhira Houhou-Fidouh  6 , Diane Descamps  3 , Charlotte Charpentier  3 , Benoit Visseaux  3
Affiliations
Comment

Alpha (B.1.1.7) and Delta (B.1.617.2 - AY.40) SARS-CoV-2 variants present strong neutralization decay at M4 post-vaccination and a faster replication rates than D614G (B.1) lineage

Samuel Lebourgeois et al. J Infect. 2022 Mar.
No abstract available

Keywords: BNT162b2 vaccine; Delta; Replication rate; SARS-CoV-2; Seroneutralization; Vaccination.

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Conflict of interest statement

Declaration of Competing Interest The authors have no relevant competing interest to disclose in relation to this work.

Figures

Fig 1
Fig. 1
Evaluation of viral production kinetics for Delta (B.1.617.2 – AY.40) strain, in blue, Alpha (B.1.1.7), in green and B.1, in red. Viral production has been assessed on two cell lines, Vero E6 and A549, and by RT-qPCR for RNA viral load, plaque assay for infectious particles and ELISA for N antigen production assessment. Results were obtained in triplicates (indicated by dot shapes).
Fig 2
Fig. 2
Seroneutralization titers obtained among vaccinated healthcare workers for B.1, Alpha (B.1.1.7) and Delta (B.1.617.2 – AY.40) strains up to 4 months after the second vaccine dose. The A panel present the seroneutralization titers kinetics for each vaccinated HCWs. The administration of the second dose, 30 days after the first dose, is indicated by the vertical dashed line. The B panel represent median and interquartiles at each evaluated time point (i.e. day 0, week 4, week 8 and week 20 after the first vaccine dose).
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